阿托伐他汀联合缬沙坦治疗慢性肾炎的疗效及对C反应蛋白的影响  

Effect of combined atorvastatin and valsartan on chronic nephritis and CRP

作　　者：景蕊[1] 

机构地区：[1]第四军医大学西京医院肾脏内科,陕西西安710032

出　　处：《解放军医学院学报》2014年第4期335-337,共3页Academic Journal of Chinese PLA Medical School

摘　　要：目的探讨阿托伐他汀联合缬沙坦对慢性肾炎患者的疗效。方法选取本院2010年6月-2012年12月60例慢性肾炎患者,随机分为观察组和对照组,每组各30例。观察组给予阿托伐他汀联合缬沙坦治疗,对照组给予阿托伐他汀治疗。比较两组在治疗前和治疗20周后24 h尿蛋白定量、血肌酐、血尿素氮、动脉血压及C反应蛋白(C-reactive protein,CRP)的变化。结果经过20周的治疗,两组24 h尿蛋白量均有显著下降(P<0.05),观察组的疗效优于对照组(P<0.05);两组血肌酐和尿素氮虽均有下降,但差异均无统计学意义(P>0.05);两组血压与治疗前比较均有不同程度下降(P<0.05),观察组疗效优于对照组(P<0.05);观察组CRP浓度较治疗前明显下降(P<0.05),对照组CRP浓度与治疗前相比差异无统计学意义(P>0.05),观察组疗效显著优于对照组(P<0.05)。结论阿托伐他汀联合缬沙坦治疗慢性肾病,对患者的尿蛋白、血压及CRP浓度的改善有积极作用,值得在临床进行推广。Objective To study the effect of combined atorvastatin and valsartan on chronic nephritis. Methods Sixty chronic nephritis patients admitted to our hospital from June 2010 to December 2012 were randomly divided into observation group and control group （30 in each group）. Patients in observation group received combined atorvastatin and valsartan treatment and those in control group received atorvastatin treatment. Their 24 h urinary protein level and serum levels of creatinine, blood urea nitrogen and CRP, and blood pressure were measured and compared before treatment and 20 weeks after treatment. Results The 24 h urinary protein was significantly lower in two groups 20 weeks after treatment than before treatment （P 〈 0.05） and the curative effect was better in observation group than in control group （P 〈 0.05）. No significant difference was found in serum creatinine and usea nitrogen level between the two groups although they were lower after treatment than before treatment （P 〉 0.05）. The blood pressure was significantly lower in two groups after treatment than before treatment （P 〈 0.05） and the curative effect was better in observation group than in control group （P 〈 0.05）. No significant difference was found in serum CRP level in control group before and after treatment （P 〉 0.05） although the curative effect was better in observation group than in control group （P 〈 0.05）. Conclusion Combined atorvastatin and valsartan can decrease the blood urinary protein level, blood pressure and serum CRP level in chronic nephritis patients and is thus worthy of application in clinical practice.

关 键 词：慢性肾炎 血管紧张素受体拮抗剂 阿托伐他汀 缬沙坦 

分 类 号：R692.3[医药卫生—泌尿科学]