冠状动脉疾病应用ATP负荷与腺苷负荷下血流储备分数评价比较  

Flow reserve score evaluation under the application of ATP and adenosine loads for coronary artery disease

作　　者：吴法令[1] 

机构地区：[1]大连大学附属中山医院,辽宁大连116001

出　　处：《中国继续医学教育》2014年第1期8-9,共2页China Continuing Medical Education

摘　　要：目的：探讨静脉泵入三磷酸腺苷（ATP）。方法选取2012年1月~2013年3月某院收治并行冠状动脉造影与FFR测定患者共32例25处病变,行腺苷测定FFR后行ATP测定,同时监测心电图、心率、主动脉压、获取有效FFR时间等指标,统计患者不适症状,分别就两组指标对比。结果测定均获得成功, QCA平均直径狭窄程度62%至84%,平均（74.6±4.26）%,获得腺苷负荷与ATP负荷下FFR值分别为（0.804±0.028）与（0.804±0.026）,获得QCA与腺苷与ATP测定FFR相关系数分别为-0.942、-0.937呈高度负相关；两组FFR结果相关系数1.0034,呈高度正相关；两种负荷测定时均出现17例不适,差异不具备统计学意义（P〉0.05）。结论采用外周静脉注射ATP负荷行FFR测定效用与腺苷负荷效用基本相同,可采用ATP替代。Objective To investigate the intravenous infusion of adenosine triphosphate （ATP）. Methods From January 2012 to March 2013 in a hospital were underwent coronary angiography and FFR were measured in 32 patients with 25 lesions, for determination of adenosine FFR followed by ATP assay, while monitoring the electrocardiogram, heart rate, pulse pressure, get effective active FFR time and other indicators, statistics the symptoms of patients, respectively, two groups of indicators contrast. Results The determination were successful, the QCA mean diameter stenosis 62%to 84%, averaged （74.61±4.26）%, obtain adenosine and ATP loads FFR values were （0.804±0.028） and （0.804±0.026）, QCA and ATP determination of adenosine and FFR correlation coefifcients were-0.942,-0.937 was highly negative correlation;two groups of FFR results in a correlation coefifcient of 1.0034, showed a highly positive correlation;two kinds of load measurement showed 17 cases of discomfort, the difference was not statistically signiifcant （P〉0.05）. Conclusion The use of peripheral intravenous injection of ATP load and adenosine for FFR determination of utility is basically the same, can be replaced by ATP.

关 键 词：冠状动脉疾病 腺苷 血流储备分数 

分 类 号：R543[医药卫生—心血管疾病]