静息态功能磁共振在新生儿脑损伤中的应用研究  

Application research of resting state functional magnetic resonance imaging in newborn brain damage

作　　者：李红新[1] 屠文娟[1] 高敏[2] 江凯华[3] 董选[3] 

机构地区：[1]常州市儿童医院新生儿科,江苏常州213003 [2]常州市儿童医院放射科,江苏常州213003 [3]常州市儿童医院儿童健康研究中心,江苏常州213003

出　　处：《中华实用儿科临床杂志》2014年第5期386-389,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：新生儿脑损伤是新生儿死亡和儿童期致残的主要原因，现阶段的主要问题是对该部分患儿脑损伤的特点、客观的预后评估和早期干预的定位判断及康复后的疗效分析等方面存在一定困难，静息态功能磁共振（rs—fMRI）不需要受试者完成复杂的任务，适合新生儿脑功能的研究。目前关于rs—fMRI脑损伤方面的报道多是来自成人的研究，新生儿方面的研究甚少，国外目前也主要集中在新生儿脑发育的研究上。如果能够对新生儿脑损伤方面开展此项的研究，并获得有价值的研究成果，将不仅有助于更加全面、准确地了解新生儿缺氧缺血性脑病患儿脑损伤组织的结构和功能，而且还可以为临床提供更多更有价值的信息。Newborn brain damage is the main cause of new-borns＇ death and disabilities. Current research dif- ficulties lie in analyzing characteristics of cerebral injuries, making objective prognosis and early intervention, as well asanalysis of therapeutic effects after recovery. Since subjects are not requested to complete complex tasks while doing resting state functional MRI （rs-fMRl） tests, rs-fMRI is reckoned to be suitable for neonatal brain function research. So far, most rs-fMRI reports regarding cerebral injury are for adults, with only a few have been done on neonates. Foreign research are mainly focused on new borns＇ brain development. If relevant rs-fMRI research can be done on newborn brain damage, it would be helpful to accurately evaluate structure and function of patients＇ brain tissue damage. Further research can provide more valuable information in clinics.

关 键 词：静息态功能磁共振 脑损伤 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]