柴苓降脂颗粒治疗脂肪肝合并高脂血症104例临床观察  

Clinical study on the therapeutic effects of Chailing lipid-lowering granule in 104 cases with hepatic steatosis and hyperlipemia

作　　者：范志刚[1] 贾高锁 梁培福 郭淑玲[3] 解鹏飞[1] 范志强[3] 

机构地区：[1]临汾职业技术学院,山西临汾041000 [2]临汾市第二人民医院,山西临汾041000 [3]临汾职业技术学院第二附属医院,山西临汾041000

出　　处：《中国医院药学杂志》2014年第7期558-561,共4页Chinese Journal of Hospital Pharmacy

基　　金：山西省科技攻关计划项目课题(编号:20090312023)

摘　　要：目的:评价柴苓降脂颗粒治疗痰湿郁阻型脂肪肝合并高脂血症的有效性和安全性。方法:选择痰湿郁阻型脂肪肝合并高脂血症患者210例,符合全分析集(FAS)患者205例,其中柴苓降脂颗粒观察组104例,对照组101例,均为10d1个疗程,连续3个疗程治疗结束后,以肝脏B超,血脂3项结合中医证候的改善评价有效性,以不良反应、实验室检查及心电图评价安全性。结果:两组治疗后中医证候结合B超检查,总有效率比较组间差异具有统计学意义(P<0.01),观察组总有效率为90.38%,优于对照组总有效率为62.37%。2组治疗后,肝区不适或隐痛,脘腹胀闷,周身困重,评分较治疗前均降低(P<0.01),并且观察组治疗后明显低于对照组,差异具有统计学意义(P<0.01)。两组治疗后,观察组丙氨酸氨基转移酶(ALT)较治疗前降低,差异具有统计学意义(P<0.01),对照组ALT较治疗前降低,差异亦有统计学意义(P<0.05),组间比较差异具有统计学意义(P<0.01)。2组治疗后,血脂TC、TG、LDL-C降低与治疗前比较,差异有统计学意义(P<0.01),治疗后,组间比较差异有统计学意义(P均<0.01),观察组优于对照组。2组治疗后,各项安全性指标与不良反应症状的观察记录与治疗前比较均无统计学意义(P>0.05)。结论:柴苓降脂颗粒对痰湿郁阻型脂肪肝合并高脂血症患者有较好的治疗作用,且临床应用安全。OBJECTIVE To observe the effect and safety of Chailing lipid-lowering granule on treating stagnation of phlegm damp resistance type of hepatic steatosis and hyperlipemia. METHODS Totally 210 patients with stagnation of phlegm damp resistance type of hepatic steatosis and hyperlipemia were randomly assigned to the treatment group （104 cases） and the control group （101 cases）. The therapeutic course for all cases was one month. Clinical symptoms were observed, blood lipids, adverse reactions, electrocardiogram examination and TCM syndromes were evaluated before treatment and at one month after treatment. RESUTS Patients＇ TCM syn- dromes and electrocardiogram examination were significantly improved in the treatment group. Its effective rate of improved symptoms was 90. 38% （P〈0. 01） in the treatment group, symptoms such as discomfort and pain of liver area, abnormal distension and ALT were slowed. Blood lipid TC, TG, and LDL-C were lowered after treatment, superior to that in the control group 62. 37%. But there was no statistical difference in adverse reaction and safety between the two groups （P〈0. 05）. CONCLUSION Chailing lipid-lowering granule showed better effects on treatment of stagnation of phlegm damp resistance type of hepatic steatosis and hyperlipemia. It had better improvement of clinical symptoms with reliable efficacy.

关 键 词：柴苓降脂颗粒 脂肪肝 痰湿郁阻证 脂肪肝中药治疗 

分 类 号：R285[医药卫生—中药学]