腺苷蛋氨酸治疗慢性乙型肝炎肝内胆汁郁积的疗效观察  

The therapeutic effects of S-adenosylmethionine on chronic hepatitis B with intrahepatic cholestasis

作　　者：史涛[1] 闵峰[1] 张丽[1] 范荣华[1] 叶会丽[1] 

机构地区：[1]中国人民解放军第174医院,福建厦门361002

出　　处：《中国医院药学杂志》2014年第7期571-573,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：观察腺苷蛋氨酸治疗慢性乙型肝炎伴肝内胆汁郁积的疗效和副作用。方法：80例病人随机分成2组,治疗组用腺苷蛋氨酸治疗慢性乙型肝炎伴肝内胆汁郁积,对照组用门冬氨酸钾镁治疗,疗程4～6周。观察结束后,对症状、体征、肝功能的变化进行分析和对比。结果：治疗后,乏力、纳差、腹胀、瘙痒、肝区不适等症状治疗组较对照组明显改善（P〈0.05）;血清总胆红素（TBil）,直接胆红素（DBil）,谷氨酰转肽酶（γ-GT）,碱性磷酸酶（AKP）,总胆汁酸（TBA）,丙氨酸转移酶（ALT）,天门冬氨酸转移酶（AST）较对照组下降明显（P〈0.01）。结论：腺苷蛋氨酸治疗慢性乙型肝炎伴肝内胆汁郁积的疗效优于门冬氨酸钾镁,无明显不良反应,其安全有效,促进肝脏的修复。OBJECTIVE To observe the therapeutic effects effects and side effcts of S-adenosylmethionine on chronic hepati- tis B with intrahepatic cholestasis. METHODS 80 cases of patients with chronic hepatitis B were divided into two groups ran- domly. The treatment group was treated with S-adenosylmethionine injected intravenously. The control group was treated with potassium-magneium aspartate. After 4-6 weeks treatment, the changes of patients＇ symptoms, signs, liver function were ana- lysed. RESULTS After treatment with S-adenosylmethionine, the clinical manifestations including feebleness, anorexia, ab- dominal distension, nausea, pruritus were significantly ameliorated than those of control. The indexes of hepatic functions （such as Tbil, DBil, AKP, r-GT, TBA, ALT, AST） were decreased obviously in the treatment group than those of control（P 〈0. 01）. CONCLUSION The results indicated that S-adenosylmethionine was good efficacy with little side effect.

关 键 词：腺苷蛋氨酸 病毒性肝炎乙型 胆汁郁积 

分 类 号：R969[医药卫生—药理学]