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作 者:陈莉[1] 王长连[1] 龚世菊[1] 陈雄刚[2]
机构地区:[1]福建医科大学附属第一医院药学部,福建福州350005 [2]福建医科大学附属第一医院麻醉科,福建福州350005
出 处:《中国医院药学杂志》2014年第7期574-576,共3页Chinese Journal of Hospital Pharmacy
基 金:福建省科技厅重点基金课题(编号:2008Y0039)
摘 要:目的:探讨不同剂量氟比洛芬酯对子宫肌瘤手术患者血浆前列腺素E2(PGE2)和白细胞介素-6(IL-6)的影响。方法:选择ASAⅠ~Ⅱ级择期子宫肌瘤切除术女性患者40例,随机分为4组:空白对照组(K0组)、不同剂量FA给药组(K1、K2、K3组),每组10例;4组病例分别于手术切皮前15min静脉注射生理盐水、FA0.5,1,1.5mg·kg^-1,待术中切除肿瘤组织时,抽取静脉血以ELISA法检测血浆中PGB和IL-6浓度。结果:4组病例血中POE2、IL-6浓度皆随着FA给药剂量的增加呈现下降趋势,组间比较差异具有统计学意义(P〈0.01)。结论:氟比洛芬酯可以降低血中致炎因子PGG和IL-6的浓度,并呈一定的剂量依赖性。OBJECTIVE To study the effects of preincisional intravenous flurbiprofen axetil on PGFa and IL-6 in uterine leio- myoma. METHODS 40 cases of ASA Ⅰ - Ⅱ female patients undergoing elective surgery of uterine leiomyoma were randomly divided into four groups: comparative group(K0 group), different doses of flurbiprofen axetil injected groups (K1, K2, K3 groups)(n = 10). The 4 groups were injected physiological saline, flurbiprofen axetil 0. 5, 1, 1.5 mg·kg^-1 respectively 15 min before skin incision, when the tumor tissue incised, the blood collected, PGE2 and IL-6 of plasma were detected by ELISA. RE- SULTS The plasma PGE2, IL6 in K0, K, , K2, K3 groups decreased along with the dose, the differences among 4 groups were significant(P〈0.01 ). CONCLUSION Flurbiprofen axetil administration could dose-dependent decrease the expression of PGE2 and IL-6 in plasma.
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