Wistar大鼠二年喂养对其生存、体质量、进食量及自发性肿瘤发生率的观察与分析  

Observation and Analysis of Survival,Body Weight,Food Intake,Spontaneous Tumorigenesis of Wistar Rats Feeding for Two Years

作　　者：肖成荣[1] 谭洪玲[1] 马增春[1] 王宇光[1] 梁乾德[1] 赵永红[1] 宁志强 王德文[1] 孙敬翔[3] 高月[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]深圳微芯生物科技有限责任公司,深圳518057 [3]南京军区杭州疗养院海勤疗养区,杭州310002

出　　处：《实验动物科学》2014年第1期34-40,共7页Laboratory Animal Science

摘　　要：目的 Wistar大鼠二年喂养对其生存、体质量及进食量进行观察与分析。方法对Wistar大鼠连续2年观察其肿瘤发生及生存情况。每周测定大鼠的体质量和进食量。结果雄性大鼠死亡率、死亡动物平均活存时间具有高于雌性大鼠的趋势,雌性大鼠的自发性肿瘤发生率较雄性大鼠略高,并且存在同一只大鼠多器官发生肿瘤的现象。实验期间雌雄大鼠进食量与进水量无明显变化,体质量在实验早期持续增长,在实验中晚期达到峰值,此后略有下降。日摄食量与体质量百分比在实验早期呈下降趋势,在实验中晚期达到极小值后略有回升。结论建立了Wistar大鼠实验室相关的正常值参考范围,为建立和开展新药对啮齿类动物致癌性试验的评价提供依据。In order to measure survival, body weight and food intake of Wistar rats feeding for two years, tumor occurrence and survival of Wistar rats were observed for two years, and food intake and body weight were investigated weekly. The results showed mortality and survival time of male rats were higher than female rats, spontaneous tumor incidence of female rats were slightly higher than male rats, and multi-organ tumors were found in one animal. Compared with female rats, food intake and water intake of male rats had no apparent change trends. Body weight grew obviously in earlier and obtained peak later, and then declined slightly. Daily food consumption and body weight percentage declined earlier in the test, and slightly rebounded after the minimum value was reached. Normal reference range of Wistar rats feeding for two years was set up in order to evaluate rodent animals carcinogenicity for new drug.

关 键 词：WISTAR大鼠 生存 致癌性 体质量 进食量 

分 类 号：Q95-33[生物学—动物学]