响应面法优化超声辅助提取荷叶中总生物碱的工艺研究  

Optimization of ultrasound-assisted extraction of alkaloids from nelumbinis folium by response surface methodology

作　　者：范杰平[1] 秦玉[1] 

机构地区：[1]南昌大学环境与化学工程学院,江西南昌330031

出　　处：《南昌大学学报（工科版）》2014年第1期1-6,共6页Journal of Nanchang University(Engineering & Technology)

基　　金：国家自然科学基金资助项目(20806037;21366019);江西省青年科学家(井冈之星)培养对象计划资助项目(20112BCB23002);江西省教育厅落地计划资助项目(KJLD-13012)

摘　　要：荷叶是一种常见药食两用的药材,具有明显的降脂作用,它的主要活性成分就是所富含的生物碱。为提高提取效率,采用超声辅助提取荷叶中的生物碱。考察了最佳提取溶剂和单因素,通过响应面分析对工艺条件进行优化及验证。结果表明:最佳提取条件为提取时间51 min,乙醇体积分数80%,液料比27 mL/g,pH 4,温度为50℃。在该条件下,总生物碱的提取率为1.07%。Lotus leaves, a kind of traditional chinese medicine used both in food and medicine fields, have sig- nificant lipid-lowering effect, whose active ingredients are rich of bio-alkaloid. In order to improve the extraction effi- ciency, ultrasound-assisted extraction of alkaloids in lotus leaf was studied in the paper. The optimum extraction sol- vent and single factor were investigated. Then the process condition was analyzed and optimized by response sur- face. The results showed that the optimum extraction conditions were 51 min, 80% ethanol, 1 ： 27 g/mL, pH 4,50 ℃. Under the conditions,the total yield of alkaloids was 1.07%.

关 键 词：荷叶 生物碱 超声波 提取 单因素 响应面分析 

分 类 号：TQ640.4[化学工程—精细化工]