不同剂量瑞舒伐他汀对老年慢性心力衰竭患者临床疗效及血浆脑钠肽的影响  

Effects of different doses of rosuvastatin on the efficacy and the level of plasma brain natriuretic peptide in the elderly patients with chronic heart failure

作　　者：庄文翔[1] 张鹏翎[1] 丁林锋[1] 

机构地区：[1]江苏省省级机关医院老年科,江苏省南京市210024

出　　处：《实用老年医学》2014年第3期238-240,共3页Practical Geriatrics

摘　　要：目的探讨10 mg、20 mg的瑞舒伐他汀对老年慢性心力衰竭(CHF)患者临床疗效及血浆脑钠肽(BNP)的影响。方法 90例老年CHF患者随机分为10 mg瑞舒伐他汀治疗组(A组)、20 mg瑞舒伐他汀治疗组(B组)及对照组,每组各30例。对照组患者给予抗心力衰竭的常规治疗;其他2组在给予对照组同样治疗基础上分别加用瑞舒伐他汀10 mg和20 mg,晚餐时服用,1次/d。3组均治疗6月。分别于治疗前及治疗后测定左室心功能及血浆BNP水平。同时观察临床症状、体征及药物不良反应。结果治疗6月后A、B组总有效率显著高于对照组(P<0.05或P<0.01);心功能指标及血浆BNP水平的改善均明显优于对照组(P<0.05或P<0.01)。且B组改善幅度最大(P<0.05或P<0.01)。结论老年CHF患者在常规治疗同时加用瑞舒伐他汀治疗可以显著降低血浆BNP水平,改善心功能。瑞舒伐他汀20 mg治疗效果优于10 mg。Objective To investigate the effects of 10 mg or 20 mg of rosuvastatin on the efficacy and the level of plasma brain natriuretie peptide （BNP） in the elderly patients with chronic heart failure （CHF）. Methods Ninety elderly patients with CHF were randomly divided into 10 mg rosuvastatin（A） group, 20 mg rosuvastatin（B） group with 30 cases in each group and control group with 30 cases in each group.The control group received routine treatment for heart failure; A group and B group received 10 mg or 20 mg rosuvastatin additionally on the basis of the routine treatment. Three groups were treated for 6 months.The left ventrieular cardiac function and plasma level of BNP were measured before and after 6 months＇ treatment, and at the same time the clinical symptoms, signs and adverse drug reactions were observed. Results After 6 months＇ treatment,compared with the control group, the total effective rate of A group and B group was significantly higher （ P〈0. 05 or P〈0. 01 ） , and the indicators of cardiac function and plasma BNP level were significantly improved（ P〈 0. 05 ,or P〈0. 01 ）.Compared with A group, the improvement of the above indicators of B group was more significant（ P〈 0. 05 or P〈0. 01）. Conclusions Rosuvastatin combined with conventional treatment can significantly reduce the plasma BNP levels, and improve heart failure in the elderly patients with CHF. 20 mg rosuvastatin was more effective than 10 rag.

关 键 词：瑞舒伐他汀 老年人 慢性心力衰竭 脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]