慢性酒精中毒性疾病与泛素-蛋白酶体途径异常调节的研究  

Abnormal Regulation of Ubiquitin-Proteasome Pathway in Chronic Alcoholism

作　　者：杨海玉[1] 刘勇[2] 

机构地区：[1]江西省人民医院临床医学研究所,南昌330006 [2]江西省人民医院病理科,南昌330006

出　　处：《南昌大学学报（医学版）》2014年第1期81-84,共4页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81060111)

摘　　要：泛素-蛋白酶体途径是细胞内蛋白质降解的主要途径,在多种细胞生命过程中发挥重要作用。目前研究证实慢性酒精中毒可导致泛素-蛋白酶体途径异常调节,主要涉及蛋白酶体活性、泛素分子合成以及相关蛋白分子表达改变等,并且与一些慢性酒精中毒性疾病的发生有关,包括酒精中毒性肝病、酒精中毒性脑病和酒精中毒性肌病。这些发现为进一步揭示酒精诱导损伤的分子机制以及研发治疗慢性酒精中毒性疾病的新型药物提供了重要的研究方向。Ubiquitin-proteasome pathway is the main way for intracellular protein degradation and plays an important role in a variety of cellular processes.Studies have confirmed that chronic alcoholism leads to abnormal regulation of ubiquitin-proteasome pathway involving alterations of proteasome activity,ubiquitin synthesis and related protein expression.Moreover,the abnormal regulation of ubiquitin-proteasome pathway is correlated with the pathogenesis of chronic alcohol-ic diseases,including alcoholic liver disease,alcoholic encephalopathy and alcoholic myopathy. These findings provide an important research direction for further revealing the molecular mecha-nisms of alcohol-induced tissue inj uries and developing new drugs for the treatment of chronic al-coholic diseases.

关 键 词：慢性酒精中毒 泛素-蛋白酶体途径 组织损伤 

分 类 号：R595.6[医药卫生—内科学]