盐酸丁咯地尔的药效学研究  

Effects of Buflomedil on Pharmacodynamic Properties

作　　者：沈建平[1] 张银娣[1] 严汉英[2] 戴德哉[3] 陈小祥[1] 蒲军 郑玉红 陆伟 杨平[3] 

机构地区：[1]南京医科大学临床药理研究所,江苏省南京市210029 [2]江苏省药物研究所药理室 [3]中国药科大学药理室

出　　处：《中国微循环》2000年第4期224-227,共4页Journal of Chinese Microcirculation

摘　　要：目的和方法用血流动力学和血液流变学方法探讨丁咯地尔(Buflomedil,Buf)多种药理活性。结果Buf在整体大鼠和离体家兔主动脉条和股动脉条上有竞争性对抗去甲肾上腺素的作用 ,但作用弱于酚妥拉明。Buf14mg·kg-1、28mg·kg-1 能显著对抗10 %高分子右旋糖酐引起的兔眼球结膜微血管血流速度减慢和管径缩小。Buf25mg·kg-1、50mg·kg-1 使家兔全血粘度明显降低。Buf50mg·kg-1 使家兔红细胞压积降低 ,血小板聚集功能下降。结论丁咯地尔不仅扩张血管 ,更重要的是能增加末梢血管或脑部缺氧组织的血供应。Objective and Method Buf is a vasoactive drug with a variety of pharmacodynamic properties. Experiments were designed to determine its haemodynamic and hemorrheological effects.Results Buf produced a weaker competitive inhibitory action of vascular constriction induced by NE than phentolamine in intact rats and in vivo preparations (rabbit chest and formal artery).Buf 14mg·kg-1, 28mg·kg-1 intravenous injection could markedly quicken the blood stream speed and dilate the conjuctive vascular bed in rabbits. Platlet aggregation and plasma viscosity were decreased and erythrocyte deformabiligy was increased by giving Buf 25mg·kg-1, 50mg·kg-1 to rabbits. Conclusions Buf is not only a vasoactive drug,importantly it seems to improve nutritional blood flow in ischaemic tissue and to increase perfusion to impaired vascular bed of the microcirculation.

关 键 词：丁咯地尔 血流动力学 血液流变学 去甲肾上腺素 

分 类 号：R972[医药卫生—药品]