针刺治疗慢性应激抑郁型大鼠的机制研究  

Mechanism Research of Acupuncture in the Treatment of Rats with Chronic Stressinduced Depression

作　　者：刘明菲[1] 燕平[1] 乔瑞瑞[1] 金晓飞[1] 王海军[1] 闫丽萍[1] 

机构地区：[1]山西中医学院,山西太原030024

出　　处：《山西职工医学院学报》2014年第1期1-3,共3页Journal of Shanxi Medical College for Continuing Education

基　　金：山西省自然科学基金项目(2012011041-3)

摘　　要：目的:研究针刺对慢性应激抑郁型大鼠的治疗机制。方法:取SD雄性大鼠随机分为3组,空白组、模型组及针刺治疗组,其中模型组给予慢性刺激、孤养、造模;针刺治疗组造模同时电针治疗。21 d后观察各组海马组织的ERK1蛋白相对含量、肾上腺质量。结果:与空白组比较,模型组、治疗组肾上腺体积均增大,体重增加,存在统计学差异(P<0.05),而模型组ERK1的蛋白含量显著减少(P<0.05),针刺组与空白组无统计学差异(P>0.05);与模型组比较,针刺组肾上腺质量与其存在统计学差异(P<0.05),针刺组ERK1蛋白相对含量较之有所升高(P<0.05)。结论:针刺治疗抑郁症能有效改善肾上腺体积增大,并能活跃ERK通路。Objective：To investigate the mechanism of acupuncture for treatment of rats with chronic stress-induced depression. Methods： SD male rats were randomly divided into three groups, including the control group, model group and acupuncture treatment group. The model group underwent chronic irritation, neonatal isolation and modeling; while the treatment group underwent modeling and synchronous electro-acupuncture treatment. 21 days later, the relative level of ERK1 and adrenal mass in the hippocampus were observed in each group. Results： Compared with the blank group, the adrenal gland volume was increased in the model group and treatment group, as well as the body weight, with significant differences （ P 〈 0.05 ） ; the protein level of ERK1 was significantly reduced in the model group （ P 〈 0.05 ）, while it was not different from the acupuncture group （P 〉 0.05 ）. Compared with the model group, the adrenal mass in the acupuncture group was statistically different （ P 〈 0.05 ） , and the relative protein level of ERK1 in the acupuncture group was increased （P 〈 0.05 ）. Conclusion： Acupuncture for treatment of depression can effectively be improved in the adrenal gland volume, and actively increase the ERK pathway.

关 键 词：抑郁症 电针 免疫组化 肾上腺指数 ERK1 

分 类 号：R335.4[医药卫生—人体生理学]