体外循环下心脏手术后认知功能障碍危险因素的研究进展  

Research Progress of Risk Factors for Postoperative Cognitive Dysfunction in Patients after Cardiac Surgery Undergoing Cardiopulmonary Bypass

作　　者：涂杰[1] 张炳东[1] 

机构地区：[1]广西医科大学第一附属医院心血管病研究所手术麻醉室,南宁530021

出　　处：《医学综述》2014年第6期1047-1050,共4页Medical Recapitulate

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2012109)

摘　　要：术后认知功能障碍(POCD)是体外循环下心脏手术后常见的中枢神经系统并发症,可严重影响患者的预后。目前病因和发病机制尚不清楚,多认为是由患者自身(年龄、术前合并症、受教育程度等)、手术(类型和炎性反应)、体外循环(白细胞激活、肝素使用和温度管理等)及麻醉药物和麻醉深度等多种因素共同作用下导致的神经功能退行性变。该文就近年来体外循环下心脏手术后POCD的相关危险因素进行综述,为早期干预提供依据。Postoperative cognitive dysfunction（POCD） is the common central nervous system complication in patients after cardiac surgery undergoing cardiopulmonary bypass, which affects the prognosis of the patients. The pathogenesis of POCD remains unclear yet, now is major thought as the neurological hypofunction related to the patient＇s own situation （age, preoperative complication, education degree ）, surgery （type and inflammatory response） , cardiopulmonary bypass（ white cell activation, heparin usage and temperature manage- ment etc. ）, anesthesia drug and depth. Here is to make a review of the risk factors of POCD in patients after cardiac surgery undergoing cardiooulmonarv bypass, to orovide evidence for early intervention.

关 键 词：术后认知功能障碍 体外循环 心脏手术 危险因素 

分 类 号：R614[医药卫生—麻醉学]