钯催化官能化芳基膦酸二乙酯的合成研究  

Synthesis of Functionalized Aryl Phosphonates by Pd Catalyzed Cross-coupling of Aryl Halides with Diethyl Phosphite

作　　者：周敬杰[1] 李斌[1] 彭进松[1] 

机构地区：[1]东北林业大学理学院黑龙江省阻燃材料分子设计与制备重点实验室,黑龙江哈尔滨150040

出　　处：《精细化工中间体》2014年第1期34-37,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金资助项目(21174025)

摘　　要：通过对催化剂、配体、碱、溶剂的优化筛选,以官能化卤代芳烃与亚磷酸二乙酯为反应原料,以无水乙醇为溶剂,Pd(OAc)2为催化剂,PPh3为配体,Et3N为碱,在80℃下反应24 h,以60%左右的收率合成得到了系列芳基膦酸二烷基酯衍生物,其结构经FT-IR,1H NMR和13C NMR表征。The palladium catalyzed arylation of diethyl phosphite with functionalized aryl halides was examined. With Pd（OAc）2（2%,n/n） as the catalyst, PPh3（6%,n/n）as the ligand, and Et3N as the base, the reaction was carried out in ethanol at 80℃ for 24 hours, affording the corresponding diethyl aryl phosphonates in moderate yields. The product structures were characterized by FT-IR, 1H NMR and 13C NMR spectra.

关 键 词：钯催化 芳基膦酸酯 交叉偶联 阻燃剂 合成 

分 类 号：TQ265.1[化学工程—有机化工]