CPAP对合并OSAHS的2型糖尿病患者脂联素水平的影响  

Effect of Continuous Positive Airway Pressure of Adiponectin in Patients with Type 2 Diabetes Mel-litus and Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：郭冠芬[1] 江宏志[2] 周美娟 黄秋霞[1] 

机构地区：[1]广东省东莞市人民医院内分泌科,广东东莞523000 [2]广东省东莞市人民医院呼吸内科,广东东莞523000 [3]广东省东莞市高埗医院内分泌科,广东东莞523000

出　　处：《医学临床研究》2014年第2期255-257,共3页Journal of Clinical Research

摘　　要：【目的】探讨持续气道正压通气（CPAP）对合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的2型糖尿病患者胰岛素抵抗（IR）及血清脂联素水平的影响。【方法】选择本院合并OSA HS的2型糖尿病患者48例，通过3个月的CPAP治疗，观察治疗前后反映 IR的稳态模式评估（HOMA ）指数及血清脂联素水平的变化。【结果】CPAP治疗3个月后，患者的 HOMA指数较治疗前明显降低（3．58＆#177;0．76 vs 1．92＆#177;0．69），血清脂联素水平较前升高（5．42＆#177;1．35 vs 8．24＆#177;1．83），且两组相比较差异均有显著性（均 P ＜0．01）。【结论】CPAP治疗可显著改善合并OSAHS的2型糖尿病患者的IR及血清脂联素水平。[Objective]To explore the effect of continuous positive airway pressure （CPAP） on insulin resist-ance（IR） and serum adiponectin level in patients with type 2 diabetes mellitus and obstructive sleep apnea hypopnea syndrome（OSAHS） .[Methods]Forty-eight patients with type 2 diabetes mellitus and OSAHS in our hospital were recruited .The homeostasis model assessment（HOMA） index and serum adiponectin level were measured before and after 3 months of CPAP treatment .[Results]Compared with before treatment ,HOMA index in patients after 3 months of CPAP treatment was significantly decreased （3 .58 ＆#177; 0 .76 vs .1 .92 ＆#177; 0 .69） ,and serum adiponectin level was significantly increased（5 .42 ＆#177; 1 .35 vs .8 .24 ＆#177; 1 .83） .There were significant difference between two groups（ P 〈0 .01） .[Conclusion]CPAP treatment can significantly improve IR and serum adiponectin level in pa-tients with type 2 diabetes mellitus and OSAHS .

关 键 词：糖尿病  2型 连续气道正压通气 脂联素 

分 类 号：R587.1[医药卫生—内分泌]