二色桌片参的化学成分研究 Ⅲ.二色桌片参多糖-1──岩藻聚糖的免疫调节作用  

Studies on the Chemical Composition of Sea Cucumber Mensamaria Intercedens Ⅲ. Immunomodulative Effects of PMI-1

作　　者：黄益丽[1] 郑忠辉[1] 苏文金[1] 陈福[1] 吴萍茹 方金瑞 

机构地区：[1]厦门大学肿瘤细胞工程国家专业实验室,厦门361005 [2]福建海洋研究所,厦门361012

出　　处：《海洋通报》2001年第1期88-91,共4页Marine Science Bulletin

摘　　要：研究了二色桌片参多糖－１（ＰＭＩ－１）在体内、体外的免疫调节作用．结果表明，二色桌片参多糖－１体外能促进小鼠脾淋巴细胞增殖，促进小鼠脾淋巴细胞分泌ＩＬ－２；体内能显著促进迟发型超敏反应，增加脾指数、胸腺指数；具有显著的免疫增强作用。The immunoactivities of PMI-1 are studied in vivo and in vitro. PMI-1(5. 50. 100u g/mL ) in vitro could promote the proliferation of mice lymphocyte, and increase IL-2 production as well. In vivo, PMI-1 could significantly improve the delayed-type hypersensitivity (DTH) degree and the weights of spleen and thymus, although it has little effect on the production of hemolysin antibodies. The results indicate that PMI-1 could remarkedly enhance the immunofunction in mice.

关 键 词：二色桌片参多糖 免疫调节 迟发型超敏反应 化学 

分 类 号：R282.77[医药卫生—中药学]