乙型肝炎病毒DNA定量与乙型肝炎五项结果的对比分析  

Comparision analysis of HBV-DNA and five items in patient with hepatitis B

作　　者：郑金菊 刘珊 王荣[2] 

机构地区：[1]青岛市中心医院检验科,青岛266042 [2]青岛市肿瘤医院,青岛266042

出　　处：《中国当代医药》2014年第9期96-97,100,共3页China Modern Medicine

摘　　要：目的探讨乙型肝炎病毒DNA定量与乙型肝炎五项的相关性。方法分别用微粒子化学发光法和荧光定量PCR法检测645例患者的乙型肝炎五项和乙型肝炎病毒DNA含量,并分析两者的关系。结果 HBsAg、HBeAg、HBcAb阳性组的乙型肝炎病毒DNA阳性率和DNA定量均显著高于其他组(P<0.05)。HBeAg阳性组乙型肝炎病毒DNA阳性率为93.4%,HBeAg阴性组乙型肝炎病毒DNA阳性率为42.8%;HBsAg阳性组乙型肝炎病毒DNA阳性率为65.3%,HBsAg阴性组乙型肝炎病毒DNA阳性率为7.4%。结论乙型肝炎病毒DNA与HBeAg呈正相关,部分HBsAg阴性患者也能检出乙型肝炎病毒DNA,乙型肝炎病毒DNA与乙型肝炎五项联合检测能更好地监测乙型肝炎病毒的复制情况,对监测疗效和判断预后有重要价值。Objective To investigate the correlation between HBV-DNA and HBV five makers.Methods Chemilumi- nescent microparticles immunoassay analysis method and fluorogenic quantitative PCR method was used to detect the HBV serological markers and HBV-DNA in 645 patients with hepatitis B respectively,and then correlation between HBV-DNA and HBV five makers was analyzed.Results HBV-DNA positive rate and HBV-DNA content in HBsAg, HBeAg and HBcAb positive group was high than that in other groups respectively （P〈0.05）.HBV-DNA positive rate in HBeAg positive group was 93.4%,HBV-DNA positive rate in HBeAg negative group was 42.8%.HBV-DNA positive rate in HBsAg positive group was 93.4%,HBV-DNA positive rate in HBsAg negative group was 42.8%.Conclusion HBV-DNA is positively correlated with HBeAg.HBV-DNA can be detected in part of HBsAg negative patients.Com- bined detection of HBV-DNA and HBV five makers can effectively monitor HBV replication,it has important value in monitoring curative effect and judging prognosis.

关 键 词：乙型肝炎病毒DNA 乙型肝炎五项 分析 

分 类 号：R512.6[医药卫生—内科学]