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机构地区:[1]深圳市药品检验所,深圳518057 [2]广东药学院,广州510006
出 处:《中国当代医药》2014年第10期9-11,15,共4页China Modern Medicine
摘 要:目的建立九味肝泰胶囊中人参皂苷Rg1及三七皂苷R1的含量测定方法,弥补该品种质量标准的不完善之处。方法采用ACQUITYBEHC18(2.1mm×50mm,1.7μm)色谱柱;流动相为乙腈一水,梯度洗脱;流速为0.4ml/min;检测波长为203nm;柱温为35℃;进样体积为μl。结果人参皂苷R勘及三七皂苷R。分别在0.10-1.50mg/ml,0.04~0.60mg/ml浓度范围内线性良好,平均回收率分别为99.4%、101.8%,RSD分别为0.5%、1.3%。结论该法方便、快速、准确,适用于九味肝泰胶囊中人参皂苷Rg。及三七皂苷R。的含量测定,可用于该制剂的质量控制。Objective To establish an UPLC method for the content determination of ginsenoside Rg and notoginseno- side RI in Jiuweigantai capsule. Methods ACQUITY BEH Cls analytical column(2.1 mmx50 mm, l.7 ixm) was used with the mobile phase consisting of aeetonitrile-water in gradient elution at a flow rate of 0.4 ml/min.The detection wave- length was 203 nm,column temperature was 35C,and injection volume was 1 ILl. Results Ginsenoside Rg, and notogin- senoside RI in Jiuweigantai capsule had good linearity within the range of 0.1-1.5 mg/ml and 0.04-0.6 mg/ml respec- tively,and their recoveries were 99.4%,101.8%,with RSD of 0.5%,1.3% respectively. Conclusion The method is conve- nient,quick,correct for determination of ginsenoside Rgl and notoginsenoside R1 in Jiuweigantai capsule,and can be used for the quality control for Jiuweigantai capsule.
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