不锈钢膜乳化法制备PLGA微球的初步研究与评价  

Study and evaluation of preparation of silybin PLGA microspheres by stainless steel membrane emulsification technique

作　　者：戎堃[1] 刘彬丽[1] 李木子[1] 许凉凉 伊辛[1] 蔡程科[2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]北京中医药大学研究生院,北京100029

出　　处：《中国中药杂志》2014年第7期1229-1233,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81173562)

摘　　要：目的:以水飞蓟宾药物为主药,利用不锈钢膜制备粒径均一的聚乳酸-羟基乙酸共聚物(PLGA)微球。方法:采用不锈钢膜乳化法,结合单因素考察优化微球的制备工艺,并对微球的平均粒径、粒径分布、载药量、包封率及体外释放等理化性质进行考察。结果:所得微球圆整度好,表面光滑,平均粒径(4.961±0.56)μm,径距(1.75±0.18),包封率(54.997±4.05)%,载药量(23.16±1.70)%。结论:不锈钢膜乳化法可用于制备中药难溶性成分水飞蓟宾PLGA微球,且所制备的微球粒径均一可控,有较大的开发价值。Objective： The aim of the present study was to prepare uniform-sized silybin loaded poly （lactic-co-glycolic acid） （PLGA） microspheres in study of silybin with stainless steel membrane. Method： Silybin PLGA microspheres were prepared by stain- less steel membrane emulsification. The preparation conditions were optimized by single-factor test and orthogonal experiment, and evaluating the mean diameters, the particle size distribution, drug loading, entrapment efficiency and morphology of microsphere. Re- suit： Prepared microspheres were round and surface was smooth. The mean diameter was （4. 961 ±0. 56） μm. The span was （1.75 ±0. 18）. The entrapment efficiency was （54. 997 ±4. 05）% and the average drug loading was （23. 16 ± 1.70）%. Conclusion： The stainless steel membrane emulsification can be used to prepare the silybin PLGA microspheres. The mean diameters of the silybin PLGA microspheres can be controlled in certain level. Stainless steel membrane emulsification has great potentiality exploitation and utilization.

关 键 词：不锈钢膜乳化法 水飞蓟宾 PLGA微球 

分 类 号：R283.6[医药卫生—中药学]