红花注射液对冬眠心肌血运重建的临床研究  

Clinical research of safflower injection on hibernating myocardial revascularization

作　　者：郑昌柱 鲜玉琼[2] 陈静[2] 徐迎辉[2] 施倩[3] 王玉华[2] 居海宁[2] 

机构地区：[1]上海市浦东新区周浦医院心血管内科,上海201318 [2]上海市第七人民医院心血管内科,上海200137 [3]上海市第七人民医院超声诊断科,上海200137

出　　处：《中国中药杂志》2014年第7期1311-1314,共4页China Journal of Chinese Materia Medica

摘　　要：冠状动脉粥样硬化性心脏病是导致人类死亡的主要疾病之一。红花改善心肌灌注作用日益引起关注。该研究采用低剂量多巴酚丁胺药物负荷超声心动图试验诊断冬眠心肌,共93例患者入选,分为红花治疗组(n=34),介入治疗组(n=33)和对照组(n=26)。3组均于试验前和随访3个月后查静息超声心动图,比较治疗前后左室收缩末(ESV)、舒张末容积(EDV)、左室壁阶段运动积分指数(WMSI)及左室射血分数(LVEF),判断3组冬眠心肌及心功能恢复情况,探讨中药红花注射液对冠心病冬眠心肌血运重建的作用及心功能的影响。研究结果显示红花组和介入组治疗后LVEF较治疗前显著提高,而ESV和WMSI显著降低,同对照组具有显著差异,治疗后红花组与介入组ESV,WMSI以及LVEF比较无显著差异。该研究认为红花注射液有效改善冬眠心肌功能。Coronary artery disease（CAD） is one of the leading causes of death. Safflower attracts great attention owing to its anti-ischemia/reperfusion injury effect. Ninety-three patients with CAD were included and randomized into safflower treatment group, PCI group and control group. Low-dose dobutamine stress echocardiography（DSE） was performed to measure end-systolic volume （ESV）, end-diastolic volume （EDV）, left ventricular ejection fraction （LVEF） and wall motion score index （WMSI） to determine the recovery of hibernating myocardium and cardiac function in all patients before treatment and after 3-month follow-up. The study was to investigate the effects of safflower on hibernating myocardial revascularization and cardiac function.It was found that LVEF was significantly improved, while the ESV and WMSI were significantly reduced after 2-week treatment in safflower and PCI treatment groups. No significant differences were found between safflower and PCI treatment groups in ESV, EDV, WMSI and LVEF after treatment. Safflower injection effectively improved hibernating myocardial function.

关 键 词：红花 冬眠心肌 心脏功能 

分 类 号：R541.4[医药卫生—心血管疾病]