益气通络法治疗肺络闭阻、气阴两虚型特发性肺纤维化的临床研究  

YiQiTongLuo Method in Treating Idiopathic Pulmonary Fibrosis: A Clinical Trial

作　　者：李艳艳[1] 张燕萍[2] 王书臣[2] 苗青[2] 张琼[2] 王冰[2] 樊茂蓉[2] 

机构地区：[1]中国科学院半导体研究所,北京100083 [2]中国中医科学院西苑医院,北京100091

出　　处：《时珍国医国药》2014年第3期630-632,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金课题(No.30901948);中国中医科学院西苑医院院内课题(No.xyky-mp-05);北京市科学技术委员会课题(No.Z131107002213053)

摘　　要：目的评价益气通络法(肺痹通方)治疗特发性肺间质纤维化患者的临床疗效及安全性。方法将52例特发性肺间质纤维化患者随机分为两组,观察组予以肺痹通方治疗,对照组予以强的松治疗,疗程12周。结果肺痹通方及激素均能改善患者综合疗效(P<0.05),但二者之间无统计学差异;肺痹通方能够明显改善患者气短气急、干咳、疲倦乏力及胸痛胸闷症状(P<0.05),而激素仅能改善患者疲倦乏力症状(P<0.05),且肺痹通方对患者胸闷胸痛的缓解作用优于强的松(P<0.05);激素组患者肺活量明显下降(P<0.05),肺痹通方能更有效地延缓患者一氧化碳弥散量的下降(P<0.05);肺痹通方比强的松更明显改善患者生活质量(P<0.05)。观察患者未发现不良反应。结论肺痹通方治疗特发性肺间质纤维化患者,在改善临床症状、提高患者生活质量、增加活动耐力等方面均有显著疗效。Objective To investigate the clinical effect and safety of yiqitongluo method （feibitongfang） on patients with idiopathic pulmonary fibrosis. Methods The 52 patients were randomly divided into the treatment and control groups. The treatment group is treated with Feibitongfang. The control group is treated with prednisone. The therapeutic course of both the groups was 12 weeks. Results Feibitongfang and prednisone can improve comprehensive curative effect,but the treatment group had not improved com- pared with the control group in it. Feibitongfang had bigger improvement in the symptoms of dyspnea, dry cough, chest complaint （ P 〈 0.05 ）. There was no significant difference for the patients of the control group in relieving languor and debilitation after trea- ting. For pulmonary function after the treatment there was no effect improved in the treatment group compared with pretherapy（P 〉 0. 05）. The VC （ % ） significantly decreased in the control group after treating （P 〈 0.05）. And for the changing of the DLCO （ % ） between the two groups there was significantly difference （ P 〈 0. 05 ）, the effect of the control group was better than that of the treatment group. There was no adverse reactions in the treatment group. Conclusion Patients with IPF may benefit from the treat- ment with Feibitongfang, can delay the progression of disease and improve the quality of life.

关 键 词：特发性肺间质纤维化 益气通络法 肺功能 动脉血氧分压 

分 类 号：R256.19[医药卫生—中医内科学] R259[医药卫生—中医学]