1992至2007年多省市队列人群血清总胆固醇水平的变化特点  

Serum total cholesterol change from 1992 to 2007 in the general population from Chinese multi-provincial cohort study

作　　者：王薇[1] 刘静[1] 王淼[1] 孙佳艺[1] 刘军[1] 齐玥[1] 解武祥[1] 赵冬[1] 

机构地区：[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病研究室,100029

出　　处：《中华心血管病杂志》2014年第3期230-235,共6页Chinese Journal of Cardiology

基　　金：＂十一五＂国家科技支撑计划（2006BAI01A02）;＂十二五＂国家科技支撑计划（2011BAI09B01,2011BAI11B03）;国家自然科学基金（81170266,81070226,81000109）

摘　　要：目的 分析1992至2007年多省市队列人群血清总胆固醇（TC）水平及高胆固醇血症患病率的变化特点.方法 1992年,在多省市35 ～64岁人群中进行基线危险因素调查,并建立心血管病研究队列.2007年,在该队列人群中再次组织危险因素调查.2次调查资料均完整的调查对象共5 740名,对其血清TC进行分析.结果 （1）1992至2007年,平均TC水平男性从4.65 mmol/L增加到4.96 mmol/L,女性从4.40 mmol/L增加到5.35 mmol/L.高胆固醇患病率男性从5.1％（141/2 791）上升到8.5％（237/2 791）,女性从4.9％（143/2949）上升到20.0％（590/2949）.（2）在不同性别中,女性基线时35 ～44岁年龄段人群平均TC水平增加值最大,为0.95 mmol/L.在不同地区中,基线时TC平均值最低的农村人群平均TC水平增加值最大,为0.88 mmol/L.以1992年基线TC水平5分位切点分层,男女两性均是最低分位组平均TC水平增加值最大,分别为0.93 mmol/L和1.45 mmol/L.（3）在2007年的高胆固醇血症患者中,36.5％ （302/827）来源于基线TC5.18～6.21 mmol/L人群,49.6％（41 0/827）来源于基线TC ＜5.18 mmol/L人群.结论 1992至2007年,队列人群平均TC水平男女两性均增高；农村以及基线TC水平最低分位组人群TC水平上升幅度最大.Objective To describe the changes of serum total cholesterol （TC） and the prevalence of hypercholesterolemia from 1992 to 2007 in the general population from Chinese muhi-provincial cohort study （CMCS）. Methods CMCS database were established on participants aged 35 -64 years from 11 provinces during the baseline examination on cardiovascular risk factors in 1992. Participants were followed up and invited to re-examine risk factors in 2007. Five thousand seven hundred and forty participants with complete data from these two examinations were included in this study for investigating the changes of serum TC level. Results （ 1 ） From 1992 to 2007, the mean level of TC increased from 4.65 mmol/L to 4.96 mmol/L for men, and from 4.40 mmol/L to 5.35 mmot/L for women. The prevalence of hypereholesterolemia increased from 5.1% （ 141/2 791 ） to 8.5% （237/2 791 ） in men, and from 4. 9% （ 143/2 949） to 20. 0% （590/2 949） in women. （2） Stratified by sex and age, the maximum increase in TC of 0. 95 mmoL/L was observed in women aged 35 - 44 years. Stratified by district, the maximum increase in TC of 0. 88 mmol/L was observed in participants who had low baseline TC level living at rural area. Furthermore, baseline TC level was categorized into quintiles, the increases in TC level were highest in the lowest quintile both in men and women （0. 93 mmol/L and 1.45 mmo]/L, respectively ）. （3） Thirty-six point five percent （302/827）participants with hypercholesterolemia in 2007 developed from those with baseline TC 5.18 -6. 21 mmol/L, and 49.6% （410/827） developed from those with baseline TC 〈 5. 18 mmoL/L. Conclusions From 1992 to 2007, the mean level of TC increased in both men and women. The greatest increases in TC were observed in the participants with the lowest quintile of baseline TC and those living in the rural area.

关 键 词：胆固醇 队列研究 流行病学 

分 类 号：R589.2[医药卫生—内分泌]