乌市体检人群高尿酸血症患病率及其肾损害相关分析  

High Uric Acid Hematic Disease and Renal Damage Epidemiological Studies in Urumqi Check-up Crowd

作　　者：朱梦[1] 王梅红[1] 刘健[1] 

机构地区：[1]新疆医科大学第一附属医院肾病科,乌鲁木齐830054

出　　处：《中国中西医结合肾病杂志》2014年第2期125-128,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：新疆自治区内科学重点学科基金资助项目

摘　　要：目的:探讨新疆乌鲁木齐市健康体检人群中高尿酸血症(HUA)的发病情况及与慢性肾脏病(CKD)的关系。方法:回顾性分析2009年1月～2010年4月在新疆医科大学第一附属医院体检中心进行健康体检的10 025例人群,了解乌市健康体检人群HUA以及危险人群CKD的患病情况。结果:在资料完整的10 025例中,HUA的患病率为14.85%%,其中HUA组CKD的患病率为11.63%,明显高于血尿酸正常组;HUA组蛋白尿的发病率为6.66%,明显高于血尿酸正常组;HUA组eGFR下降的患病率为5.21%,明显高于血尿酸正常组;而两组血尿的发病率差异无统计学意义。多因素Logistic回归提示,高尿酸血症(OR=1.36,95%CI=1.13～1.65)、性别(OR=1.44,95%CI=1.25～1.67)、收缩压≥140 mmHg(OR=1.78,95%CI=1.49～2.73)、高血糖(OR=1.36,95%CI=1.67～2.58)是CKD重要危险因素。结论:乌鲁木齐市健康体检人群中HUA的患病率为14.85%,加强高危群筛查,积极控制血尿酸、血糖、血压可减少CKD的发生和发展。Objective：To investigate the prevalence of hyperuricemia and its relationship with chronic kidney disease （CKD） in Urumqi check - up crowd. Methods：A total of l0 025 subjects who were older than 20 years and received healthy examina tion in Health Center of the First Affiliated Hospital,Xinjiang Medical University, from January 2009 to April 2010 were enrolled. Re- suits： （1） the prevalence of huperuricemia was 14.85% ; （2） In people with hyperuricemia , the prevalence of CKD was l I. 63%, the prevalence of Proteinuria was 6.66%, the prevalence of GFR decline was 5.21%. They were significantly higher than in those with normal blood uric acid. There were no significant difference in the prevalence of hematuria in both ; （ 3 ） Logistic regression analysis showed：HUA , gender, systolic blood pressure I〉 140 mmHg, hyperglycemia were the important risk factors for CKD. Conclusion：The prevalence of hyperuricemia was 14.85% in Urumqi check - up crowd. It can reduce the occurrence and development of CKD to Strengthen screening of the high - risk group, control of blood uric acid, glucose, blood pressure positively.

关 键 词：高尿酸血症 慢性肾脏病 患病率 

分 类 号：R589.7[医药卫生—内分泌]