环境因素导致肾脏损害的表观遗传学机制  

Epigenetic mechanisms of environmental factors-induced kidney injury

作　　者：曹香华 秦卫松[1] 

机构地区：[1]南京军区南京总医院国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2014年第1期73-78,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金面上项目(81270811);国家重点基础研究发展计划(973计划)[2012CB517600(2012CB517605)]

摘　　要：环境因素(化学物质、物理射线、生物因素等)的暴露与多种肾脏疾病的发生发展密切相关,其中表观遗传学机制起着至关重要的作用。近年来,环境表观遗传学的研究逐渐成为热点,环境因素可通过影响表观遗传修饰的改变,直接或间接导致疾病的发生发展,促进糖尿病肾病及其他慢性肾脏病的进展。本文综述了环境表观遗传学修饰在肾脏损伤中的作用及机制。Exposure to the environmental factors, including chemicals, radiations, biological, etc, is related with various kidney diseases. Epigenetic mechanisms play import roles in the injury of environmental factors. Environmental epigenetics has become a hot topic in recent years. Environmental factors can affect the epigenetic alteration and results in the occurrence and development of diseases, including the diabetic nephropathy and other chronic kidney diseases. This review focus on the the roles and mechanisms of environmental epigenetics in kidney injuries.

关 键 词：肾脏损害 环境暴露 表观遗传学 

分 类 号：R692[医药卫生—泌尿科学]