男性不育的表观遗传学研究进展  

Progress in epigenetic research on male infertility

作　　者：刘运强[1] 卢永杰[1] 张思仲[1] 

机构地区：[1]四川大学华西医院医学遗传研究室暨生物治疗国家重点实验室疾病基因组学研究室,成都610041

出　　处：《中华医学遗传学杂志》2014年第2期170-173,共4页Chinese Journal of Medical Genetics

摘　　要：男性不育是影响人类健康和社会生活的主要疾病之一，受众多遗传和环境因素的共同影响。DNA的表观修饰因应环境因素调节在精子生成过程中发挥着重要作用。表观遗传修饰异常将会对精子数量和质量产生影响，导致男性生殖障碍。本文对近年来DNA甲基化、组蛋白修饰、非编码RNA等表观调控异常与男性不育的关系研究进展进行了综述。Male infertility is one of the major diseases that affect human health and social life, and is influenced by many genetic and environmental factors. Epigenetic modification on DNA strands in response to environmental factors plays an important role in the process of spermatogenesis. Abnormalities of epigenetic regulation may affect both the quantity and quality of sperm production and result in disorders of male reproduction. We hereby review recent progress made in research on epigenetic regulation including DNA methylation, histone modification and non-coding RNA related with male infertility.

关 键 词：男性不育 DNA甲基化 组蛋白修饰 非编码RNA 表观调控 

分 类 号：R698.2[医药卫生—泌尿科学]