结缔组织相关性胃肠疾病研究现状  

Current Status of Research on Connective Tissue-related Gastrointestinal Disorders

作　　者：吕健[1,2] 殷晓星[1,2] 马保金[1,2,3] 

机构地区：[1]上海市静安区中心医院 [2]复旦大学附属华山医院静安分院普外科,200040 [3]复旦大学华山医院普外科

出　　处：《胃肠病学》2014年第3期181-184,共4页Chinese Journal of Gastroenterology

摘　　要：结缔组织是细胞附着、移动、增生、分化和发挥细胞特殊功能的骨架。大量证据表明,胃肠疾病的发生与结缔组织的变化密切相关。狭义的结缔组织相关性胃肠疾病称为结肠结缔组织病(DC),表现为结肠固有肌层结缔组织先天性发育不良或后天性萎缩继而影响胃肠蠕动。广义的结缔组织相关性胃肠疾病除固有肌层结缔组织网减少或缺失外,还包括全身性结缔组织病引发的胃肠道胶原增生或纤维化。局灶性结缔组织的缺失是肠憩室和穿孔的主要原因。本文就结缔组织相关性胃肠疾病的研究现状作一综述。Connective tissue is the framework on which cells adhere, migrate, proliferate, differentiate, and perform specific cellular functions. Compelling evidences suggest that gastrointestinal disorders are closely associated with connective tissue abnormalities. Gastrointestinal disorders involving connective tissue in strict sense is described as desmosis coli （DC） , manifesting disturbed peristalsis with congenital aplasia （aplastic form） or acquired atrophy （atrophic form） of muscularis propria connective tissue of colon. In broad sense, gastrointestinal disorders involving connective tissue also includes disorders involving gastrointestinal collagen hyperplasia or fibrosis associated with systemic connective tissue diseases. Focal absence of connective tissue is the main cause of intestinal diverticulosis and perforation. This article reviewed the current status of research on connective tissue-related gastrointestinal disorders.

关 键 词：结缔组织疾病 胃肠疾病 纤维化 胶原 

分 类 号：R593.2[医药卫生—内科学]