HIV辅助蛋白拮抗细胞限制因子机制研究进展  

Research Progress in HIV Auxiliary Proteins Counteracting Host Restriction Factors

作　　者：陈倩倩[1] 徐庆刚[1] 张驰宇[1,2] 

机构地区：[1]江苏大学生命科学研究院,镇江212013 [2]中国科学院上海巴斯德研究所病原诊断中心,上海200025

出　　处：《病毒学报》2014年第1期84-90,共7页Chinese Journal of Virology

基　　金：国家自然基金"81271888""81071391"

摘　　要：抗病毒限制因子成为病毒学研究领域的热点。近些年陆续发现了4种HIV限制因子:APOBEC3G、Trim5α、Tetherin、SAMHD1。其中APOBEC3G、Tetherin、SAMHD1分别被HIV编码的辅助蛋白Vif、Vpu、Vpx所拮抗。这些辅助蛋白影响病毒的致病性和复制能力,拮抗宿主内的天然抗病毒限制因子,使病毒能够成功的侵染宿主细胞。本文重点综述了这三种能拮抗宿主限制因子的HIV辅助蛋白的功能研究进展。Abstract：Identification and functional analyses of antiviral restriction factors in hosts have become hot research topics. Four HIV restriction factors, APOBEC3G, Trim5a, Tetherin, and SAMHD1, have been identified in recent years. By encoding auxiliary proteins, lentiviruses can counteract host restriction factors. For example, the auxiliary proteins Vif, Vpu, and Vpx of HIV antagonize APOBEC3G, Tetherin, and SAMHD1, respectively. Furthermore, these auxiliary proteins enable the entry of HIV into host cells and influence the replication and pathogenicity of HIV. In this paper, we review the research progress in the functions of the three HIV auxiliary proteins that can antagonize the host restriction factors.

关 键 词：HIV辅助蛋白 限制因子 VIF VPU VPX 

分 类 号：R373.9[医药卫生—病原生物学]