乙型脑炎病毒侵染细胞机制的研究进展  

Research Progress in Mechanisms of Cellular Entry of Japanese Encephalitis Virus

作　　者：周雅娴[1] 张建琼[1] 

机构地区：[1]东南大学医学院,南京210009

出　　处：《病毒学报》2014年第2期188-192,共5页Chinese Journal of Virology

基　　金：东南大学教学改革研究项目(2010-079);东南大学大学生科研训练项目(SRTP)项目(13412012)

摘　　要：乙型脑炎病毒是一种蚊媒致病病毒,能引发严重的病毒性脑炎。乙脑病毒入侵细胞是导致乙型脑炎发生的先决条件,入侵机制的阐明将为乙型脑炎的治疗提供更多途径。近年来,乙脑病毒侵染细胞机制的研究不断深入,其他黄病毒的研究成果也拓展了乙脑病毒入侵机制的研究方向。E蛋白抗体的研制以及侵染过程抑制物的发现为乙脑病毒入侵的有效阻断提供了更多的可能。本文就近年来乙脑病毒入侵及膜融合的相关研究进展做一综述。Japanese encephalitis virus （JEV） is a pathogenic mosquito-borne flavivirus which is responsible for outbreaks of severe viral encephalitis. The cellular entry of JEV is a prerequisite for Japanese encephalitis, so the understanding of its underlying mechanisms will provide more approaches for treating such disease. In recent years, increasing research has been conducted to investigate the mechanisms of cellular en- try of JEV, and the results of research on other flavivirus have expanded the research directions for JEV. More methods will be used to suppress JEV infection because of the development of E protein antibodies and the discovery of several inhibitors of the cellular entry process. This review will summarize the recent advances in the mechanisms of JEV cellular entry and membrane fusion.

关 键 词：乙型脑炎病毒 包膜蛋白E 内吞作用 膜融合 

分 类 号：R373.3[医药卫生—病原生物学]