健康中年男性人体成分对骨密度的影响  

Effect of body composition on bone mineral density in healthy middle-aged men

作　　者：杨莉丽[1,2] 于雪梅 陈培红 金华 高婷[3,4] 谢心苗[1,2] 杨梅丽[3,4] 

机构地区：[1]南方医科大学第三临床医学院内分泌代谢科,广州510515 [2]南方医科大学附属奉贤医院内分泌代谢科,上海201400 [3]上海市奉贤区中心医院内分泌代谢科,上海201400 [4]苏州大学医学部,苏州215123

出　　处：《中国骨质疏松杂志》2014年第3期242-246,共5页Chinese Journal of Osteoporosis

基　　金：上海市卫生局资助项目(2009225);上海市医学重点专科建设计划(ZK2012B16)

摘　　要：目的：探讨健康中年男性人体成分对骨密度影响，为男性骨质疏松早期防治提供理论依据。方法以上海市奉贤区128名年龄为40～60岁（平均49.10＆#177;6.40岁）的健康中年男性为研究对象，测定其身高、体重、腰围、臀围，并计算体重指数（ BMI）；利用问卷调查调查其文化程度、饮酒吸烟、豆制品及奶制品摄入情况、静坐时间、睡眠时间等一般情况；利用全自动生化分析仪测定血钙（Ca）、血磷（P）、肝肾功能（ALT、AST、BUN、Cr、UA）、血脂（TC、TG、HDL、LDL）、血糖（FPG、2h-PG），高压液相法测定糖化血红蛋白（HbA1c）等生化指标；采用双能X线骨密度仪测定腰椎、股骨颈、股骨干、股骨大粗隆和全身骨密度（ BMD），并根据T值或Z值评分结果将所有研究对象分为骨量正常组和骨量低下组；采用人体成分分析仪测定体脂肪含量、蛋白质含量、无机盐含量、骨骼肌含量和各部位肌肉含量。结果128名年龄为40～60岁健康中年男性中，骨质疏松患者3人，骨量减少患者44人。骨量正常组体重、BMI、腰围、臀围、睡眠时间、蛋白质含量、无机质含量、骨骼肌含量、各部位肌肉含量皆高于骨量低下组，血清尿素及吸烟人数比率低于骨量低下组，且差异具有统计学意义；两组年龄、身高、饮酒情况、文化程度、工作性质、豆制品摄入情况及奶制品摄入情况、Ca、P、Cr、UA、ALT、AST、TC、TG、HDL、LDL、FPG、2h-PG、HbA1c、体脂肪及体脂百分比皆无统计学差异。结论适当延长每天睡眠时间有利于预防骨质疏松的发生；体重、BMI、腰围、臀围是骨质疏松的保护因素，但需通过加强体育锻炼及合理饮食，增加骨骼肌、无机质及蛋白质等非脂肪含量来增加骨密度预防骨质疏松。Objective To investigate the effect of body composition on bone mineral density （ BMD ） in healthy middle-aged men, and to provide theoretical basis for the early prevention and treatment of male osteoporosis.Methods One hundred and twenty-eight healthy middle-aged men, aging between 40 and 60 years old, with an average age of 49.10 ±6.40 years old, from Fengxian District in Shanghai were enrolled in this study.The height, weight, waistline, hipline of all the subjects were measured. Body mass index （ BMI） was calculated.The educational background, drinking and smoking history, intake of bean products and milk, sedentary time, hours of sleep were surveyed using a questionnaire.At the same time, blood calcium （ Ca）, blood phosphorus （ P） , the indexes of liver and kidney function （ ALT, AST, BUN, Cr, and UA） , blood lipid levels （ TC, TG, HDL, and LDL）, blood glucose （FPG, 2h-PG） were detected using automatic biochemical analyzer.The level of HbA1c was detected using high pressure liquid chromatography.The bone mineral density （ BMD） of the lumbar vertebrae, the left proximal femur, the femoral shaft, and the whole bones was detected using dual-energy X-ray absorptiometry.The fat mass, protein mass, mineral salt mass, skeletal muscle mass, and muscle of each segment were measured using human body composition analyzer.Results Among all the subjects, 3 had osteoporosis and 44 had osteopenia.The weight, waistline, hipline, BMI, hours of sleep, fat mass, protein mass, mineral salt mass, skeletal muscle mass, and muscle of each segment in normal group were much higher than those in osteopenia group, and the blood urea and the ratio of smoking were lower than those in osteopenia group （P〈0.05）.However, no significant difference of age, height, educational background, drinking, intake of bean products and milk, sedentary time, blood Ca, P, Cr, UA, ALT, AST, TC, TG, HDL, LDL, FPG, 2h-PG, and HbA1c, fat mass, and the percentage of body fat was observed between the two groups.Conclusio

关 键 词：中年男性 骨密度 人体成分 

分 类 号：R68[医药卫生—骨科学]