长期小剂量甲巯咪唑与碘131治疗对复发甲状腺功能亢进患者骨密度、心脏功能以及生化指标的影响  

Effect of long-term small dose of methimazole and radioiodine 131 on bone mineral density, cardiac function,and biochemical indexes during the treatment of recurrent hyperthyroidism

作　　者：随华[1] 耿秀琴[1] 周艳红[1] 

机构地区：[1]新乡市中心医院内分泌科,新乡453000

出　　处：《中国骨质疏松杂志》2014年第3期282-284,共3页Chinese Journal of Osteoporosis

基　　金：新乡市2013年重点科技攻关计划项目(ZG13028)

摘　　要：目的比较长期服用小剂量甲巯咪唑与应用同位素治疗对甲状腺功能亢进复发者的骨密度、心脏功能以及生化指标的影响。方法 62名甲状腺功能亢进复发患者,随机分为药物治疗和同位素治疗两组。28例长期口服甲巯咪唑,34例接受同位素治疗。随访期间,测试所有患者甲状腺功能、血脂、心脏彩超、骨密度等。结果 28例药物治疗组和13例同位素治疗组患者甲状腺功能都正常,而21例同位素治疗患者出现甲状腺功能减退。药物治疗组比同位素治疗组患者血脂更低,而骨密度、白细胞、肝脏功能、心脏功能无差异。结论与同位素治疗相比,长期服用小剂量甲巯咪唑治疗甲亢复发患者是安全的。Objective To compare the effect of long-term small dose of methimazole or radioiodine 131 on bone mineral density （ BMD） , cardiac function, and biochemical indexes in patients with recurrent hyperthyroidism.Methods Sixty-two patients with recurrent hyperthyroidism were randomly divided into two groups： drug treatment group and radioiodine treatment group.Twenty-eight patients took a long-term oral medication of methimazole, while 34 patients were given a radioiodine treatment.During the follow-up, the thyroid function, serum lipids and lipoproteins, echocardiography, and BMD were detected.Results The thyroid function of 28 patients in drug treatment group and 13 patients in radioiodine treatment group was normal, while the other 21 patients in radioiodine treatment group had hypothyroidism.The serum levels of lipids in drug treatment group were much lower than that in radioiodine treatment group, while no difference of BMD, white blood cell, liver function, and cardiac function was observed between the two groups.Conclusion Compared with radioiodine treatment, long-term small dose of methimazole treatment is safe for patients with recurrent hyperthyroidism.

关 键 词：甲状腺功能亢进 同位素治疗 骨密度 甲巯咪唑 

分 类 号：R581.1[医药卫生—内分泌]