微量元素与骨质疏松的相关性研究进展  

Research progress of Trace elements and Osteoporosis

作　　者：雷鹏蛟 王亮[2] 马远征[2] 杨国花[2] 李大伟[2] 胡江伟[2] 付雪梅[2] 

机构地区：[1]山西医科大学,山西太原030001 [2]解放军第309医院骨科,北京100091

出　　处：《中国骨质疏松杂志》2014年第3期343-346,共4页Chinese Journal of Osteoporosis

基　　金：全军十二五课题(CWS11J169)

摘　　要：骨质疏松症(Osteoporosis OP)是一种以骨量低下,骨微结构破坏,导致骨脆性增加,易发生骨折为特征的全身性骨病。微量元素是人和动物骨骼生长及发育所必需的,在骨骼的新陈代谢和骨转换中有重要的地位。骨的代谢受许多全身和局部调节因子的调节,矿物质和微量元素通过直接或间接的方式作用于骨细胞并影响骨代谢。例如氟集中在新骨构成的部位并促进网状结构增加骨量;铝通过阻止成骨细胞的功能而导致骨基质的破害;镁通过刺激破骨细胞的功能促进骨转换;锌通过甲状腺来调节钙分泌并影响骨转换,也可促进成骨细胞样细胞的生长、分化,有助于骨的钙化;铜通过抑制成骨细胞和破骨细胞的功能而导致低骨转换;碘参与甲状腺激素的构成而加强骨转换。另外,微量元素在人体新陈代谢中的也有其特殊作用,如铜、锰、锌等参与一些酶的组成及功能活动,他们通过对这些酶的调节来影响骨的代谢;硒则可以通过硒蛋白的抗氧化作用来维持正常的骨代谢;锰参与活化硫酸软膏素的合成酶系统,能促进成骨细胞分化。本文主要对锌、硒、锰、锶与骨质疏松症关系的研究进行综述,为微量元素应用于骨质疏松的防治提供理论依据。Osteoporosis （ OP） is a systemic bone disease featured with low bone mass density, bone fragility due to bone micro-structural damage and prone to fracture.Trace elements in human and animal bones is necessary for growth and development,and play an important role in bone metabolism and turnover.Bone metabolism is regulated by many factors through systemic or local way, and is effected by minerals and elements acting on bone cells directly or indirectly.For example, fluorine concentrate at the site of new formed bone prmoting mesh structure and increaing bone mass;aluminum broken bone matrix by destroying the function of osteoblasts;magnesium promote bone turnover by stimulating osteoclast function;zinc act on the thyroid to regulate the secretion of calcium, affect bone turnover;,and promote the growth and differentiaion of osteogenesis conductine to bone calcification;copper inhibit osteoblasts and osteoclasts function leading to low bone turnover; iodine involved in the composition of thyroid hormone leading to low bone turnover.In addition, there are trace elements playing special role in human metabolism, such as copper, manganese, zinc and other activities involved in the composition and function of some enzymes, they regulate these enzymes to effect bone metabolism;selenium can maintain normal bone metabolism by selenoproteins antioxidative;Manganese is involved in activation of chondroitin sulfate synthetase system, and can stimulate the differentiation of osteoblasts.This paper riviews the research of zinc, selenium, manganese and strontium in osteoporosis, and provides theoreitc evidence for the prevention and treatment of osteoporosis using trace elements.

关 键 词：微量元素 骨质疏松症 

分 类 号：R681[医药卫生—骨科学]