长期缺氧对婴幼儿肠道菌群代谢的影响  

Chronic hypoxia in altering metabolism of intestinal flora of infants

作　　者：文仁国[1] 孙国林[1] 彭晓波[1] 马瑞岩[1] 肖颖彬[1] 

机构地区：[1]第三军医大学新桥医院心血管外科,重庆400037

出　　处：《局解手术学杂志》2014年第2期121-122,124,共3页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的探讨长期缺氧对紫绀先天性心脏病婴幼儿肠道菌群代谢的影响。方法将我院住院治疗的法洛四联症患儿10例设为缺氧组,健康同龄儿童10例为对照组。核磁共振波谱仪(1H-NMR)检测禁食后清晨尿液马尿酸含量。结果缺氧组与对照组的马尿酸含量分别为(47.15±32.88)mg/L和(346.698±13.555)mg/L,有显著性差异,P=0.002。结论长期慢性缺氧会影响婴幼儿肠道菌群代谢。Objective To investigate the metabolism change of intestinal flora due to chronic hypoxia in infants. Methods Ten infants with tetralogy of fallot were considered as the chronic hypoxia group,10 healthy infants were regarded as the control group. The urine concen-tration of hippurate in the morning with fasting was detected by 1 H nuclear magnetic resonance. Results The concentration of hippurate was decreased in hypoxia group compared with the control group,（47. 15 ± 32. 88） mg/L vs （346. 698 ± 13. 555） mg/L,with significant differ-ence,P=0. 002. Conclusion Chronic hypoxia alters metabolism of intestinal flora in infants.

关 键 词：长期缺氧 婴幼儿 肠道菌群 马尿酸 代谢 

分 类 号：R378.2[医药卫生—病原生物学] R364.4[医药卫生—基础医学]