乌司他丁对兔非通气侧肺功能的保护作用  

The Protective Effect of Ulinastatin for Rabbit Non-ventilated Lung Function

作　　者：陈剑锋[1] 陈少娟[1] 庄小雪[1] 

机构地区：[1]广州医学院第一附属医院麻醉科,广州510012

出　　处：《中国医药导刊》2013年第12期2017-2018,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨乌司他丁对兔非通气侧肺功能的保护作用。方法:将30只家兔随机平分为对照组(A组),肺损伤对照组(B组)和乌司他丁治疗组(C组),B组和C组形成急性肺损伤模型,其中,B组采取生理盐水进行静脉滴注,C组采取10000单位/Kg的乌司他丁进行静脉滴注,手术中观察动物的基础值,记录相关数值并取肺楔形病理切片。结果:(P<0.05)B组的肺体质量比值以及肺水含量均明显高于A组和C组,(P>0.05)A组与C组数据差异无统计学意义。与A组比较,B组动物在创伤后30分钟PaO2明显降低,(P<0.05)两组数据差异具有统计学意义,并在4h内维持在较低水平。而C组动物的PaO2水平于30分钟先降低,2h后明显升高,(P<0.05)两组数据差异具有统计学意义。结论:乌司他丁能够改善术中单肺通气的血气指标,对其肺功能有一定的保护作用,值得推广应用。Objective：To investigate the protective effect of ulinastatin for rabbit non-ventilated lung function. Methods：30 rabbits were randomly equally divided into control group （A）, lung injury control group （B group） and UTI treatment group （C group）, B and C group were form of acute lung injury model, B group were given by ear vein saline infusion, C group were given by the ear vein to give UTI infusion （10,000 units/Kg）, recorded the basis for animal values and the relevant recorded values of lung wedge biopsy. Results：After observation, B group 4 hours after traumatic injury of lung body weight ratio and lung water content compared with group A and group C were significantly higher （P〈0.05）, Group A and group C showed no significant difference （P〉0.05）. A group, B group animals 30 minutes after trauma, PaO2 was significantly lower （P〈0.05）, and continued to maintain a low level in 4h. And B group, C group were lower PaO2 first 30 minutes, 2h after the last was significantly higher （P〈0.05）. Conclusion：UTI can improve intraoperative one-lung ventilation of blood gas, it has a protective effect on lung function, should be widely applied.

关 键 词：乌司他丁 急性肺损伤 兔 保护作用 

分 类 号：R614[医药卫生—麻醉学]