西罗莫司与环磷酰胺静脉冲击联合激素诱导治疗增殖性狼疮性肾炎的疗效观察  

The Clinical Efficacy of Sirolimus and Cyclophosphamide Impact the Clinical Efficacy of the Combined Hormone Induction Therapy of Proliferative Lupus Nephritis(LN)

作　　者：周亚伟[1] 

机构地区：[1]江苏省徐州市睢宁县人民医院肾内科,徐州221200

出　　处：《中国医药导刊》2013年第12期2026-2027,共2页Chinese Journal of Medicinal Guide

摘　　要：目的：探讨西罗莫司与环磷酰胺（CTX）静脉冲击联合激素诱导治疗增殖性狼疮性肾炎（LN）的临床疗效比较。方法：回顾性分析了2006年6月-2012年6月入住我院的120例增殖性狼疮性肾炎（LN）患者的临床资料，将其随机分为对照组与观察组，对照组（n=60）为使用传统的方法进行治疗，即给予CTX＋泼尼松进行治疗，观察组（n=60）给予西罗莫司＋泼尼松进行治疗，对比两组2个月与4个月的临床疗效以及两组患者治疗后的生存质量，组间差异以P〈0.05表示具有统计学意义。结果：（1）观察组治疗2个月的总有效率为83.3%（50/60），对照组为36.7%（22/60），两组存在统计学差异（P〈0.05）；观察组治疗4个月末的总有效率为88.3%（53/60），对照组为61.7%（37/60），两组存在统计学差异（P〈0.05）。（2）根据患者生存质量评价标准对两组患者的评分，对照组患者生存质量总得分为（104±6）分，观察组为（131±7）分，两组具有显著的统计学差异（P〈0.01）。结论：西罗莫司联合激素较传统的治疗方法能够快速、有效地诱导增殖性狼疮性肾炎（LN），且具有较好的安全性，值得推广。Objective： To investigate the sirolimus and cyclophosphamide （CTX） intravenous pulse the combined hormone induction therapy clinical comparison of proliferative lupus nephritis（LN）.Methods：120 cases of A retrospective analysis of the clinical data 2006.06-2012.06 check our hospital 120 cases of proliferative lupus nephritis （LN）,randomly divided into a control group and the observation group and the control group （n=60） for the use of traditional method of treatment,which is giving the CTX＋prednisone treatment, the observation group （n=60） to give sirolimus＋prednisone treatment, compared to the clinical efficacy of the two groups of 2 months and 4 months, and two groups of patients quality of life after treatment, P〈0.05 indicated a statistically significant difference between the groups. Results：The total effective rate was 83.3%（50/60）：（1） treatment of two at the end of the observation group,the control group was 36.7%（22/60）,the two groups there is a significant difference （P〈0.05）;observation group therapy 4 at the end of the total effective rate was 88.3%（53/60）,the control group was 61.7%（37/60）,the two groups there is a statistically significant difference （P〈0.05）. （2） based on patient quality of life assessment standards of the ratings of the two groups of patients,the control group patients quality of life （104±6） total score points,the observation group （131±7）,with a statistically significant difference in the two groups （P〈0.01）. Conclusion：The more traditional sirolimus combined hormone treatment can quickly and effectively induced proliferative lupus nephritis （LN）,with better security,it should be worth promoting.

关 键 词：西罗莫司 环磷酰胺(CTX) 泼尼松 增殖性狼疮性肾炎(LN) 

分 类 号：R593.242[医药卫生—内科学]