降钙素原在慢性阻塞性肺疾病急性加重期中指导抗生素使用的价值  

The value of procalcitonin in guiding antibiotic therapy in acute exacerbation of chronic obstructive pulmonary disease

作　　者：刘爱平[1] 周大明[1] 姜继军[1] 

机构地区：[1]泰州市人民医院感染病科,江苏泰州225300

出　　处：《医学检验与临床》2014年第1期25-27,共3页Medical Laboratory Science and Clinics

摘　　要：目的：评价降钙素原（PCT）对于慢性阻塞性肺疾病急性加重期（AECOPD）患者使用抗生素的指导价值。方法：本研究纳入74例AECOPD患者，随机分成PCT组和对照治疗组。其中PCT组根据PCT策略决定抗生素的使用；对照组根据患者临床症状进行经验性抗生素使用。主要观察指标包括抗生素的使用时间、住院时间、加重例数和死亡例数等。结果：两组数据结果对比显示，在死亡率和病情加重例数无显著差异的情况下，PCT组患者抗生素使用时间、住院时间明显减少，与对照治疗组具有显著差异。结论：PCT指导AECOPD抗感染治疗在不影响病情的情况下能够有效减少抗生素使用并且缩短患者的住院时间。Objective ： To assess the value of procalcitonin（PCT） in guiding antibiotic therapy for acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods ： 74 patients with AECOPD were randomly divided into two groups： PCT group, in which whether patients needed to receive antibiotic treatment depends on PCT strategy; Control group, in which clinical symptoms and experience decided whether antibiotic treatment needs to be conducted. The length of antibiotic exposure, length of hospitalization, cases of deterioration and deaths were recorded.Results ： Compared with control group, the length of antibiotic exposure and hospitalization from PCT group were significantly decreased, while there was no significant difference in cases of deterioration and deaths. Conclusions ： PCT strategy for AECOPD could reduce the dose of antibiotics and the length of hospitalization without bad outcomes.

关 键 词：慢性阻塞性肺疾病 急性加重期 降钙素原 感染 抗生素使用 

分 类 号：R563[医药卫生—呼吸系统]