埃索美拉唑镁多晶型的制备、表征及相互转化  

Preparation,Characterization and Transformation of Esomeprazole Magnesium Polymorphs

作　　者：林青 陆杰 周迅 吴丹辉 

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122

出　　处：《中国医药工业杂志》2014年第4期377-380,共4页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金(21176102;21176215);江苏省自然科学基金(BK20131100)

摘　　要：制备了4种埃索美拉唑镁晶型(二水合物A晶型、二水合物B晶型、四水合物和三水合物),并用粉末X-射线衍射、红外光谱及热失重分析等手段进行表征,建立了不同晶型的鉴定方法。确定了4种晶型的相互转化条件。In this paper, the esomeprazole magnesium polymorphs （dihydrate form A, dihydrate form B, tetrahydrate and trihydrate） were prepared. The polymorphs were characterized by powder X-ray diffraction, infrared spectroscopy and thermal gravimetric analysis. The identification of different polymorphs together with the conditions among their transformation was established.

关 键 词：埃索美拉唑镁盐 多晶型 表征 转晶 

分 类 号：R917[医药卫生—药物分析学]