基于分子印迹技术的手性药物拆分及对映体选择性释药系统研究进展  

Research Progress on Molecular Imprinting Technology Based Enantioseparation and Enantioselective Drug Delivery Systems of Chiral Drugs

作　　者：荣毅[1] 张亮[1] 俞文英[1] 叶金翠[1] 

机构地区：[1]浙江省医学科学院药物研究所,浙江杭州310013

出　　处：《中国医药工业杂志》2014年第4期381-386,共6页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(30901871);浙江省科技厅项目(2011C13003和2011F10048);浙江省医学重点学科群建设(XKQ-010-001);浙江省卫生高层次创新人才培养工程项目

摘　　要：分子印迹聚合物是一种模仿天然分子识别系统的合成材料,对模板分子有特异选择性和亲和力。若以手性药物的单对映体为模板制备分子印迹聚合物,会因其特殊的三维空腔结构而展现出对映体选择性识别的能力,故在手性药物应用研究领域发展迅速。本文综述了近年来将分子印迹聚合物用作手性固定相进行手性药物拆分,以及作为辅料用于对映体选择性智能释药系统的研究进展。Molecular imprinted polymers （MIPs） with high selectivity and affinity for the template molecules are synthetic materials which mimic natural molecularly recognition system. MIPs prepared by the single enantiomer as template show enantioselective recognition capabilities due to their special structures of the three-dimensional cavities, and the applied research in the field of chiral drugs have been developed rapidly. This paper provides an overview on the recent advances in applications of MIPs to chiral stationary phases for the enantioseparation of chiral drugs, as well as the usage for the enantioselective intelligent drug delivery systems as excipients.

关 键 词：分子印迹 手性拆分 对映体选择性释药 综述 

分 类 号：R944.9[医药卫生—药剂学]