唐松草属植物中生物碱类化学成分和药理作用的研究进展  

Research progress on chemical constituents and pharmacological activities of alkaloids from plants in Thalictrum L.

作　　者：李圣各 苏钰清[1] 马冬珂 李建勇[2] 郭佳[2] 李达翃[2] 李占林[2] 华会明[2] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳药科大学中药学院基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《现代药物与临床》2014年第3期312-321,共10页Drugs & Clinic

基　　金：国家自然科学基金资助项目(81172958);国家基础科学人才培养基金项目(J1103606)

摘　　要：毛茛科唐松草属植物由于具有较高的药用价值,在我国广泛应用。唐松草属植物的生物碱属于异喹啉类,包括生物碱单聚物如简单异喹啉类、苄基异喹啉类、阿朴菲类、原小檗碱类、吗啡烷类、异帕威类等;此外还存在大量的二聚生物碱,主要类型有双苄基异喹啉类、阿朴菲–苄基异喹啉类、原小檗碱–苄基异喹啉类、阿朴菲–原小檗碱类等;具有抗肿瘤、抗寄生虫、抗血小板聚集、抗矽肺、抗病毒等药理作用。主要对唐松草属植物中生物碱类化学成分和药理作用的研究进展进行综述,为该属植物资源的开发利用提供参考。The plants in Thalictrum L., Ranunculaceae family are widely used in China because of their officinal values. The main active constituents from Thalictrum L. are isoquinoline alkaloids including simple isoquinolines, benzylisoquinolines, aporphins alkaloids, proberberines, morphinans, and isopavines. There are also a lot of dimeric alkaloids including dibenzylisoquinolines, aporphinoid-benzylisoquinolines, proberberine-benzylisoquinolines, and aporphinoid-proberberines. In addition, they play an important role in anti-cancer, anti-parasites, anti-platelet aggregation, anti-silicosis, and anti-virus actions. This article mainly summarizes the chemical constituents and pharmacological activities of alkaloids from plants in Thalictrum L. in recent years, and provides a reference for the development and utilization of the plants of Thalictrum L.

关 键 词：唐松草属 生物碱 异喹啉类 二聚生物碱 化学成分 药理作用 

分 类 号：R282.7[医药卫生—中药学]