益肾降糖饮治疗糖尿病肾病Ⅲ期气阴两虚夹瘀疗效及舌象观察30例  

To Observe the Changes of the Tongue and the Clinical Effect on Diabetic Nephropathy Ⅲ of Qi-Yin Deficiency with Blood Stasis Syndrome for 30 Cases

作　　者：叶彬华[1] 钟索娅 张政[1] 阮诗玮[1] 

机构地区：[1]福建中医药大学附属人民医院肾内科,福州350004 [2]福建中医药大学中医内科,2009级研究生福州350122

出　　处：《中国中医药现代远程教育》2014年第5期45-47,共3页Chinese Medicine Modern Distance Education of China

基　　金：福建省卫生厅课题[No:wzzsb0908]

摘　　要：目的观察益肾降糖饮对糖尿病肾病Ⅲ期气阴两虚夹瘀证患者的治疗疗效及治疗前后舌象的变化情况。方法将60例入选的糖尿病肾病Ⅲ期气阴两虚夹瘀证患者,按简单随机法分成治疗组30例,对照组30例,治疗组在基础治疗的同时服用益肾降糖饮治疗。对照组采用基础治疗。治疗60天,观察治疗前后糖尿病肾病Ⅲ期气阴两虚夹瘀证患者中医证候变化情况,并对比治疗前后治疗组与对照组空腹血糖、餐后2小时血糖、尿微量白蛋白、肾小球滤过率、血脂等指标以及治疗前后舌象的改变。结果益肾降糖饮组治疗糖尿病肾病Ⅲ期气阴两虚夹瘀证总有效率为90.0%,两组治疗后空腹血糖(FBG)、餐后2小时血糖(P2hPG)、尿微量白蛋白、肾小球滤过率、血脂比较,经统计学处理,治疗组优于对照组(P<0.05)。两组治疗后舌象血瘀表现,经统计学处理,治疗组优于对照组(P<0.05)。结论①通过本研究可见益肾降糖饮是治疗糖尿病肾病Ⅲ期气阴两虚夹瘀证有效方剂,中西药联合治疗疗效优于单纯西医治疗,临床症状改善明显。能够有效地降低尿微量白蛋白,缓解肾功能进展。②舌象的改变可作为糖尿病肾病Ⅲ期气阴两虚夹瘀证临床疗效的一个观察指标。Objeetive To observe clinical effect of YishenjiangTang Decoction on patients with diabetic nephropathy 3（DN Ill）and relation between changes of the tongue. Methods According to the Mngensen diagnostic and classification on criterion of DN. 60 patients who were diagnosed both Qi-Yin deficiency with blood stasis syndrome with DN Ul were enrolled and divided into treatment group and control group at random. In treat- ment group there are 30 cases and it is the same in control group. Each patient from the treatment group took YishenjiangTang Decoction 30ml and twice per day,integrated with modem medicine conventional therapy,while patients from the control group only took the modem medicine. Both of the two groups took 2 months as 1 course of treatment. Syndrome of traditional Chinese Medicine and Glomerular filtration rate（GFR） were detected before and after the treatment. Results The effective rate of treatment group is 90. 0% and clinical symptoms werc improved much more than that of control group（ P 〈0.05）. After treatment,FBG,urinary albumin and tEhPG were significantly decreased compared with those of control group（ P 〈0. 05） ; and GFR were improved（before treatment,it was P 〈0. 05）. No obvious adverse reaction was found in both groups. And the tongue of the patients with blood stasis from the treatment group was better than that of the patients with blood stasis from the control group. Conclusions （1）YishenjiangTang Decoction was proved to be an effective prescription for patients who were diagnosed both Qi-Yin deficiency with blood stasis syndrome with DNIII. （2） Changes in the tongue can be used as an objective index for clinical assessment of blood stasis.

关 键 词：糖尿病肾病 益肾降糖饮 气阴两虚夹瘀 舌象 

分 类 号：R259[医药卫生—中西医结合]