益气活血、通阳化痰法对实验性动脉粥样硬化家兔血清对氧磷酶1活性的影响  

Effect on the Enzyme Activity of Paraoxonase 1(PON-1)in the Experimental Atherosclerosis Rabbits Serum by Method of the Qi-Replenishing,Blood-Activating,Yang-Invigorating and Phlegm-resolving

作　　者：杨军辉[1] 张静[1] 周小青[1] 

机构地区：[1]湖南中医药大学,长沙410007

出　　处：《中国中医药现代远程教育》2014年第6期148-149,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的观察益气活血、通阳化痰法对实验性动脉粥样硬化(AS)家兔血清对氧磷酶1(PON-1)活性的影响。方法将54只家兔随机分为6组,每组9只。分为空白对照组、模型对照组、辛伐他汀组、中药大、中、小剂量组。除空白对照组外其余各组给予高脂饲料喂养4周后开始灌胃给药,1次/d,连续4周后处死动物,测定血清PON-1活性。结果模型组的PON-1活性较空白对照组明显降低(P<0.01)。中药各剂量组可以有效地升高血清PON-1活性,其中5g/kg剂量组和模型组比较差异十分明显(P<0.01),2.5g/kg剂量组和模型组比较差异也有统计学意义(P<0.05)。结论益气活血、通阳化痰法可通过升高血清PON-1活性来防治AS。Objective To observe the effect of qi-replenishing, blood - activating, yang- invigorating and phlegm- resolving method on serum paraoxonase 1 （PON-1） activity of rabbits with experimental arteriosclerosis （AS）. Methods 54 rabbits were randomized equally into 6 groups, including blank control group, modeling group, therapy group with Simvastatin, and other 3 therapy groups with high, medium, low dosage o{ Chinese medicinal respectively. Rabbits from all groups, except blank control group, were fed with high fat diet for 4 weeks, and received intra gastric administration of medication afterwards, once daily for 4 consecutive weeks. Then all groups of rabbits were killed and tested for serum PON- 1 activity. Results Serum PON-1 activity of modeling group were significantly decreased （ P 〈0. 01 ）, compared with blank control group. All therapy groups with different dosage of Chinese medicinal can effectively rise serum PON- 1 activity, thereamong, highly significant differ ence （ P 〈0.01） was found between 5g/kg dosage group and modeling group, whereas there was also significant difference （ P 〈0. 05） between 2.5g/kg dosage group and modeling group. Conclusion qi-replenishing, blood-activating, yang-invigorating and phlegn＇eresolving method can control AS via its elevation of serum PON-1 activity.

关 键 词：益气活血 通阳化痰 动脉粥样硬化 对氧磷酶1 

分 类 号：R285.5[医药卫生—中药学]