七氟醚麻醉对低龄婴儿左心功能的影响  

Effects of sevoflurane anesthesia on left ventricular function in young infants

作　　者：孙震[1] 彭长国 吕晶[1] 潘福治[2] 乔伟[2] 任卫东[2] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳市110004 [2]中国医科大学附属盛京医院超声科,沈阳市110004

出　　处：《中华麻醉学杂志》2014年第1期9-11,共3页Chinese Journal of Anesthesiology

摘　　要：目的 评价七氟醚麻醉对低龄婴儿左心功能的影响.方法 择期拟行体表血管瘤切除术患儿16例,性别不限,28 ～ 75日龄,体重4.0～6.1 kg,ASA分级Ⅰ级.吸入6％七氟醚4min时行气管插管,机械通气,麻醉维持：吸入七氟醚,呼气末浓度4.48％ ～ 5.12％.分别于麻醉诱导前（T0）、气管插管前即刻（T1）、气管插管后10 min（T2）、气管插管后30 min（T3）、拔除气管导管后20 min（T4）、拔除气管导管后1 h（T5）时采用组织多普勒频谱技术确定Tei指数,记录术中心血管事件发生情况.结果 与T0时比较,T1-4时Tei指数增加（P＜0.05或0.01）,T5时Tei指数差异无统计学意义（P＞0.05）.术中血压和心率平稳,未发生心血管事件.结论 虽然七氟醚麻醉未诱发低龄婴儿心血管事件,但是在一定程度上降低了左心功能.Objective To evaluate the effects of sevoflurane anesthesia on the left ventricular function in young infants.Methods Sixteen ASA physical status Ⅰ pediatric patients,aged 28-75 days,weighing 4.0-6.1 kg,undergoing elective resection of hemangioma on the body surface under general anesthesia with sevoflurane were studied.After the pediatric patients inhaled 6 % sevoflurane for 4 min,tracheal intubation was performed,and the pediatric patients were mechanically ventilated.Anesthesia was maintained with sevoflurane with the endtidal concentration of 4.48%-5.12%.Transthoracic echocardiographic examinations were performed before induction of anesthesia （baseline,T0）,immediately before intubation （T1）,at 10 and 30 min after intubation （T2,3）,and at 20 min and 1 h after extubation （T4,5） to calculate Tei index.Results Compared with the baseline value at T0,Tei index was significantly increased at T1-4 （P 〈 0.05 or 0.01）,and no significant change was found in Tei index at T5 （P 〉 0.05）.The blood pressure and heart rate were stable and no adverse cardiovascular events were found during surgery.Conclusion Although sevoflurane anesthesia does not induce cardiovascular events,it decreases the left ventricular function to some extent in young infants.

关 键 词：麻醉药 吸入 婴儿 新生 心脏功能试验 

分 类 号：R726.1[医药卫生—儿科]