苯磺酸氨氯地平与硝苯地平治疗原发性老年高血压患者的疗效比较  

Comparison of Therapeutic Efficacy between Amlodipine Besylate and Nifedipine in the Treatment of Primary Elderly Hypertension

作　　者：谭晓梅[1] 林青[1] 曾芳[1] 冯绍文[1] 招彩玲[1] 

机构地区：[1]中山大学附属第一医院,广州510700

出　　处：《中国药房》2014年第16期1476-1478,共3页China Pharmacy

摘　　要：目的:观察苯磺酸氨氯地平与硝苯地平治疗原发性老年高血压患者的临床疗效和安全性。方法:160例原发性老年高血压患者按抽签法随机均分为A组和B组。A组患者给予苯磺酸氨氯地平片5 mg,口服,qd;B组患者给予硝苯地平控释片30 mg,口服,qd。两组患者用药时间均为早上6点至8点,疗程均为12个月。观察两组患者的临床疗效,治疗后的动态血压及不良反应发生情况。结果:A组患者总有效率显著高于B组,不良反应发生率显著低于B组,两组比较差异均有统计学意义(P<0.05);治疗后除A组患者夜间舒张压显著低于B组患者外(P<0.05),两组患者白天、24 h的动态血压及夜间收缩压、动脉压、心率比较差异均无统计学意义(P>0.05)。结论:在老年高血压长期降压用药方面,硝苯地平控释片与苯磺酸氨氯地平片的疗效与安全性均较好,实际选用时患者可根据自身情况择优选择,如夜晚舒张压高的患者可优先选择苯磺酸氨氯地平片。OBJECTIVE： To observe clinical efficacy and safety of amlodipine besylate and nifedipine in the treatment of prima- ry elderly hypertension. METHODS： 160 elderly hypertensive patients were randomly divided into group A and group B by means of sortition. Group A was given Amlodipine besylate tablets 5 mg orally; group B was given Nifedipine sustained-release tablets 30 mg orally, qd, from 6：00 am till 8：00 pm. Treatment course of 2 groups lasted for 12 months. Clinical efficacy, dynamic blood pressure and ADR were observed in 2 groups. RESULTS ： Total effective rate of group A was significantly higher than that of group B; the incidence of ADR in group A was significantly lower than in group B; there were statistical significance （P〈0.05）. After treatment, nocturnal DBP of group A was significantly lower than that of group B; there was statistical significance （P〈0.05） there were no statistical significance in the difference of 24 h dynamic blood pressure, nocturnal SBP, DBP, MAP and HR be-tween 2 groups （P〉0.05）. CONCLUSIONS： Amlodipine besylate is effective and safe for the long-term treatment of elderly hyper-tension, and first choice for patients with high nocturnal DBP.

关 键 词：苯磺酸氨氯地平 硝苯地平 降压 老年高血压 

分 类 号：R544.1[医药卫生—心血管疾病]