慢性心力衰竭患者血浆内脏脂肪素水平及其影响因素的研究  

Serum visfatin level and its influencing factors in patients with chronic heart failure

作　　者：邱樑 姚琪[1] 陶袁[1] 全军民[1] 

机构地区：[1]嵊州市人民医院心内科,312400

出　　处：《浙江医学》2014年第6期501-503,共3页Zhejiang Medical Journal

摘　　要：目的观察慢性左心衰竭患者的血浆内脏脂肪素水平,探讨其与糖脂代谢参数和高敏C反应蛋白(hs-CRP)的关系。方法将50例慢性左心功能不全患者(心力衰竭组)根据超声心动图左心室射血分数(LVEF)分成两亚组:轻度心功能不全亚组(35%<LVEF≤45%)25例.重度心功能不全亚组(LVEF≤35%)25例;对照组(LVEF>50%)24例,检测并比较各组hs-CRP、内脏脂肪素、血脂、血糖等指标。结果心力衰竭组内脏脂肪素较对照组降低(5.8±22.1 ng/ml vs 8 5±2 4 ng/ml。P<0 01);轻度、重度心功能不全亚组及对照组比较,内脏脂肪素、hs-CRP、血糖、HOMAIR、HDL-C差异均有统计学意义(P<0 05或0.01);内脏脂肪素与LVEF呈正相关(r=0.49,P<0.01),与hs-CRP呈负相关(r=-0.30,P<0.01)。结论心力衰竭患者的血清内脏脂肪素显著降低,此结果独立于年龄、性别、BMI和代谢参数。Objective To determine the serum visfatin levels in patients with chronic heart failure （CHF） and its influencing factors. Methods Fifty patients with chronic heart failure due to left ventricular systolic dysfunction were divided into mild HF group （35%〈LVEF≤45%, n= 25） and severe HF group （LVEF≤35%, n=25）; 24 healthy subjects （LVEF〉50%） served as control group. Serum visfatin, hsCRP, glucose and lipid metabolism parameters were measured in all subjects. Results Serum visfatin levels in HF groups were significantly lower than those in controt group （5.8 ±22.1ng/ml vs 8.5 ±2.4ng/ml, P〈0.01）. The Kruskal-Wallis test showed significant differences among three groups in serum revels of visfatin, hsCRP, glucose, HOMAIR and HDL-cholesterol（P〈0.05 or 0.01）. Serum visfatin level was positively correlated with LVEF and negatively correlated with hs-CRP （r=0.49, -0.30,P〈0.01）. Conclusion Serum visfatin levels in patients with systolic HF are decreased, which is independent to age, sex, BMI, and metabolic parameters of patients.

关 键 词：内脏脂肪素心功能衰竭高敏C反应蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]