异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液配伍的稳定性  

Compatible Stability of Magnesium Isoglycyrrhizinate Injection with 5% Dextrose Injection and 10% Fructose Injection

作　　者：夏宏[1] 耿魁魁[1] 汝婷婷[1] 倪芳芳[2] 

机构地区：[1]安徽医科大学附属省立医院药剂科,合肥230001 [2]安徽中医药大学,合肥230038

出　　处：《中国医院用药评价与分析》2014年第3期234-237,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:考察异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液2种输液配伍的稳定性。方法:将异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液按临床常用的浓度配伍,室温下放置8 h,分别于0、2、4、6、8 h取样,用高效液相色谱法测定异甘草酸镁的含量,用酸度计测定pH值,用光阻法测定其不溶性微粒。结果:异甘草酸镁注射液与上述2种注射液配伍后,8 h内的pH值、含量两项指标的变化在《中华人民共和国药典》(2010年版)规定的范围之内,但不溶性微粒指标较大,不符合相关规定。结论:异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液配伍后,含量与pH值符合《中华人民共和国药典》(2010年版)规定,但不溶性微粒指标不符合规定,建议临床不配伍使用。OBJECTIVE：To investigate the stability of Magnesium isoglycyrrhizinate injection with 5% dextrose injection and 10% fructose injection. METHODS：Magnesium isoglycyrrhizinate injection was mixed with 5% dextroseinjection or 10% fructose injection and then stored at room temperature for 8 hrs. Samples were taken at 0,2,4,6, 8 hrs respectively,with the content of magnesium isoglycyrrhizinate determined by HPLC, the pH value measured by acidometer, and the insoluble particles measured using a light blockage method. RESULTS：The mixed solutions were stable in pH value within 8 hours after mixing with 5% dextrose injection and 10% fructose injection with content changes（two indicators）within the limit specified in ＂ Chinese Pharmacopoeia＂（2010 edition）yet the indicator of insoluble particles was greater and didn＇ t meet the relevant regulations. CONCLUSION ： The content and pH value of magnesium isoglycyrrhizinate injection met the regulations of ＂Chinese Pharmacopoeia＂（2010 edition）yet the indicator of insoluble particles didn＇ t comply with the relevant regulations after mixing with 5% dextrose injection and 10% fructose injection, therefore, it is recommended that the magnesium isoglycyrrhizinate injection not mix with 5% dextrose injection or 10% fructose injection for use clinically.

关 键 词：异甘草酸镁注射液5%葡萄糖注射液10%果糖注射液配伍稳定性 

分 类 号：R965[医药卫生—药理学]