2011—2012年420例药品不良反应报告分析  

Adverse Drug Reaction Reports During 2011-2012: Analysis of 420 Cases

作　　者：胡伟[1] 慈静[1] 

机构地区：[1]威海市文登中心医院药学部,山东文登264400

出　　处：《中国医院用药评价与分析》2014年第3期257-259,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解威海市文登中心医院药品不良反应(ADR)发生的特点和规律,为临床合理用药提供参考。方法:对我院2011—2012年收集上报的有效ADR报告420例按照患者性别、年龄、给药途径、药物种类、ADR累及器官和(或)系统、临床表现、转归等进行统计、分析。结果:420例ADR中,男性214例,女性206例,男女之比为1∶1.04;ADR多发生于50岁以上人群;静脉滴注为ADR发生的主要途径,共290例(占69.05%),其次为口服给药,共81例(占19.29%);抗感染药导致的ADR为最多,共126例(占30%),其次是中药制剂,为59例(占14.05%);ADR以皮肤及其附件损害最多,共170例(占40.48%)。结论:应重视ADR的监测和宣传工作,降低ADR的发生率,促进临床合理用药,保障患者用药安全。OBJECTIVE：To investigate the characteristics and regularities of the adverse drug reactions （ADR） occurred in Weihai Wendeng Central Hospital so as to provide reference for clinical rational use of drug. METHODS： A total of 420 ADR cases reported by our hospital during 2011-2012 were registered and analyzed statistically with regard to patients＇ sex and age, route of administration, drug type, organs and（or） systems involved in ADR, clinical manifestations and outcomes etc. RESULTS： Of the 420 ADR cases, 214 were male and 206 female （with male to female ratio of 1 ： 1.04 ） ; ADR occurred more often in patients aged above 50 years, via the route of intravenous （290 cases, representing 69.05% ） followed by oral administration （81 cases; 19.29% ）, and it was induced more often by anti-infective drugs （126 patients; 30% ） followed by Chinese drug preparations （59 cases; 14. 05% ）, and manifested mainly as lesions of skin and its appendages （170 cases; 40.48% ）. CONCLUSION： Great attention should be paid to the ADR monitoring and publicity so as to reduce the incidence of ADR, promote rational use of drug and ensure patients＇ medication safety.

关 键 词：药品不良反应分析合理用药 

分 类 号：R969.3[医药卫生—药理学]