卵巢上皮性癌治疗后血清CA125再升高的治疗选择:积极化疗,抑或是观察等待?  

Potential Treatments of Serum CA125 Re-elevated Caused by Epithelial Ovarian Cancer Recurrence:Active Chemotherapy,or Passive Monitoring?

作　　者：王建[1] 陈良凤[1,2] 郑福利[1,3] 乔谷媛[1] 张潍[1] 刘淑娟[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032 [2]安康市中心医院妇产科,陕西安康725000 [3]陕西中医学院第二附属医院妇产科,陕西咸阳712000

出　　处：《医学与哲学（B）》2014年第3期90-92,共3页Medicine & Philosophy(B)

基　　金：国家自然科学基金项目;项目编号:81172458/H1621;陕西省重点课题;项目编号:2012KTCL03-08

摘　　要：卵巢上皮性癌是恶性程度、病死率极高的卵巢肿瘤,几乎所有的经规范治疗后的卵巢上皮性癌都存在复发风险,复发较大程度上意味着不良预后,甚至死亡。与卵巢癌相关的肿瘤抗原(CA125)是观察、诊断卵巢上皮性癌术后复发的敏感指标,对复发早期无影像学证据,仅单纯CA125升高的卵巢上皮性癌患者是积极化疗,抑或是观察等待?一直是妇科肿瘤学术界争论的问题。怎样既能通过积极治疗快速缓解病情,又避免过度化疗带来的副作用?本文对此争论作一讨论,以期得出明确的观点,指导临床工作。Epithelial ovarian cancer is a type of malignant ovarian cancer with a high mortality rate ,and post standard treatment epithelial ovarian cancer often recurs ,the recurrence almost always leads to poor prognosis and potential death . Serum CA125 is a valuable indicator of epithelial ovarian cancer recurrence .However ,there is still an academic debate on whether doctors should pursue active chemotherapy or continue to passively monitor patient condition once serum CA 125 has been detected at the early stage of cancer recurrence without radiographic evidence . How to rapidly alleviate the conditions while avoid the side effects caused by excessive chemotherapy ？ The manuscript discusses the above-mentioned debate and evaluates the pros and cons of each method in order to provide a guide for doctors to make the best clinical solution .

关 键 词：卵巢上皮性癌 复发 化疗 

分 类 号：R711.75[医药卫生—妇产科学]