加味柴胡舒肝散对肝郁血虚型慢性荨麻疹患者负性情绪的影响研究  

Study on Effects of Modified Chaihu Shugan Powder on Negative Emotions of Patients with Depressed Liver and Blood Deficiency Type Chronic Urticaria

作　　者：王冬梅[1] 马丽俐[2] 祝永强[1] 王一枫[1] 

机构地区：[1]浙江省立同德医院,浙江杭州310012 [2]浙江省中医院,浙江杭州310006

出　　处：《中华中医药学刊》2014年第4期814-816,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药优秀青年人才基金项目(Q564)

摘　　要：目的:探讨加味柴胡舒肝散治疗肝郁血虚型慢性荨麻疹(CU)的疗效及对汉密顿焦虑量表(HAMA)评分、人血清神经生长因子(NGF)、P物质(SP)的影响。方法:将80例肝郁血虚型CU随机设立为治疗组(口服加味柴胡舒肝散和地氯雷他定片)和对照组(口服地氯雷他定片),比较两组的疗效及两组患者6周服用的地氯雷他定片的人均片数。应用双抗体夹心法测定患者治疗前后血清中NGF和SP水平,并进行HAMA评分。选取健康体检者40例作为正常组,进行HAMA评分,检测NGF、SP水平。结果:治疗组和对照组治疗的总有效率分别为87.5%与72.5%,有统计学意义(P<0.05)。治疗组服用的地氯雷他定片人均片数较对照组明显减少,有统计学意义(P<0.05)。治疗组和对照组患者血清NGF和SP水平较正常组,有差异性(P<0.05);治疗后两组血清NGF和SP水平均显著下降,且两组组内、组间比较HAMA评分、NGF水平,均有统计学意义(P<0.05)。治疗前后两组组内SP比较有统计学意义(P<0.05),但治疗后两组的SP比较无统计学意义(P<0.05)。结论:加味柴胡舒肝散能提高治疗肝郁血虚型CU的疗效,明显减少地氯雷他定片的用量,并且能通过降低NGF水平,改善患者的焦虑等负性情绪,但对SP水平无明显影响。Objective ：To investigate the efficacy of treating depressed liver and blood deficiency type chronic urticaria （CU） with modified Chaihu Shugan powder and effect on the Hamilton Anxiety Scale （HAMA）, nerve growth factor （NGF） and substance P （SP） in serum. Methods ：80 cases of patients with depressed liver and blood deficiency type CU were randomly divided into the treatment group （orally taking modified Chaihu Shugan powder and desloratadine tablets） and control group （ orally taking desloratadine tablets） to observe the clinical efficacy and per capita comparison of deslo- ratadine tablets of the two groups after 6 weeks. Before and after treatment, serum levels of NGF and SP were determined by double antibody sandwich in patients and I-IAMA score was measured. 40 healthy subjects served as normal group and were detected serum levels of NGF, SP and HAMA score. Results ： The total effective rate of the treatment group and con- trol group was 87.5% and 72.5%, P 〈0.05, and there was a statistical significance. Compared with the control group, desloratadine tablets per capita number of the treatment group was significantly reduced, P 〈0. 05. Serum NGF and SP levels in the treatment group and the control group were higher than those in the normal group, and the two differences were significant （P 〈 0.05 ）. After the treatment, the serum levels of NGF and SP were significantly lower than that before treatment. Also after treatment, HAMA score and the serum levels of NGF compared between two groups had significant differences （ P 〈 0.05 ）. The serum levels of SP was decreased significantly （ P 〈 0.05 ） in two groups, but there was no significant difference between two groups （P 〉 0. 05）. Conclusion： Modified Chaihu Shugan powder can improve the cura- tive effect of the treatment of depressed liver and blood deficiency type CU and significantly reduce the amount of deslorat- adine tablets and can improve the patient＇s anxiety negative emotions by reducing th

关 键 词：加味柴胡舒肝散 肝郁血虚型慢性荨麻疹 神经生长因子 P物质 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]