NaBH_4/(CH_3)_2SO_4/B(OCH_3)_3复合还原体系合成2-(4-羟基苯)乙醇  

APPLICATION OF NABH_4/(CH_3)_2SO_4/B(OCH_3)_3 REDUCTIVE SYSTEM IN THE SYNTHESIS OF 2-(4-HYDROXYPHENYL)ETHANOL

作　　者：李运山[1] 李凯[1] 骆公爵 顾超力 田梦云[1] 

机构地区：[1]常州工程职业技术学院制药与生物工程技术系,江苏常州213164

出　　处：《精细石油化工》2014年第2期29-33,共5页Speciality Petrochemicals

基　　金：江苏省高等学校大学生实践创新训练计划资助项目(201313102011Y)

摘　　要：以对羟基苯乙酸为原料,用NaBH4/(CH3)2SO4/B(OCH3)3还原体系制备2-(4-羟基苯)乙醇,考察了原料配比、溶剂用量等单因素条件对目标产物收率的影响,确定了较佳工艺条件,并通过IR、HPLC和1 H NMR等对产物进行表征。结果表明:当n(NaBH4)∶n(B(OCH3)3)∶n(对羟基苯乙酸)=1.8∶1.5∶1.0,无水四氢呋喃为溶剂,B(OCH3)3滴加时间为50min,30℃搅拌反应3.5h,收率可达96%以上,质量分数为99.5%。The reduction of 4-hydroxyphenylacetic acid with sodium borohydride/dimethyl sulfate/trimethyl borate in the preparation of 2-（4-hydroxyphenyl） ethanol is described.The structure of product was characterized.Effects of key factors on target product were investigated.The results showed that the yield could be above 96 ％ and the purity was 99.5 ％ when the raw material ratio was 1.8 ∶ 1.5 ∶ 1 with THF as solvent,dripping time was 50 min and reacted at 30 ℃ for 3.5 h.

关 键 词：硼氢化钠 硼酸三甲酯 还原 2-(4-羟基苯)乙醇 

分 类 号：TQ243.4[化学工程—有机化工]