2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-羧酸乙酯缩水杨醛Schiff碱的合成  

Synthesis of Ethyl 2-( 2-Hydroxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

作　　者：杨平[1] 宋新建[1] 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《湖北民族学院学报（自然科学版）》2014年第1期54-56,74,共4页Journal of Hubei Minzu University(Natural Science Edition)

基　　金：湖北省自然科学基金项目(2011CDB087)

摘　　要：以环己酮、氰基乙酸乙酯与单质硫为原料通过三组分Gewald反应采用"一锅"法合成出2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-羧酸乙酯,再与水杨醛发生缩合反应制得相应的Schiff碱.目标化合物的结构经红外光谱、核磁共振氢谱、质谱和元素分析表征.The Schiff base ethyl 2-（2-hydroxybenzylideneamino）-4,5,6,7-tetrahydrobenzo [b]thio-phene-3-carboxylate was synthesized by the condensation reaction of salicylaldehyde with ethyl 2-amino-4,5,6,7-tetrahydrobenzo [ b] thiophene-3-carboxylate , which was efficiently prepared via a one-pot Gewald’s three-component reaction using cyclohexanone , ethyl 2-cyanoacetate and elemental sulfur as starting materials.The structure of the new compound was confirmed by IR , 1 H NMR, MS and elemental analysis.

关 键 词：Gewald反应 合成 2-氨基噻吩 SCHIFF碱 一锅法 

分 类 号：O626[理学—有机化学]