和血通脉颗粒联合西药治疗心脑合病痰瘀互结证191例临床观察  

Clinical Observation on Hexue Tongmai Granules Combined With Western Medicine for 191 Cases of CardioCerebral-Vascular Diseases With Phlegm-Stasis Intermingling Pattern

作　　者：袁东超[1] 张哲[2] 肖蕾[2] 张会永[2] 王夏云[2] 王洋[2] 齐文诚[2] 吴瑾[1] 陈丽娟[1] 杨洋[1] 杨关林[1] 

机构地区：[1]辽宁中医药大学,辽宁省沈阳市110847 [2]辽宁中医药大学附属医院

出　　处：《中医杂志》2014年第8期661-665,共5页Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研专项资助项目(200807061)

摘　　要：目的评价和血通脉颗粒联合西药治疗心脑合病痰瘀互结证的临床疗效及其与患者年龄、性别及病情程度的关系。方法将383例心脑合病痰瘀互结证患者随机分为治疗组191例和对照组192例,两组均给予西医基础治疗,治疗组加服和血通脉颗粒,对照组给予安慰剂,治疗8周后观察两组临床疗效。治疗前后比较两组中医证候总积分、心绞痛积分、美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗组临床疗效总有效率为78.01%,对照组为55.73%,治疗组优于对照组(P<0.05)。两组不同性别患者治疗后各积分值均低于治疗前(P<0.01)。治疗后治疗组不同性别患者各积分值均低于对照组,男性NIHSS评分比较差异有统计学意义(P<0.05),女性各积分差异均有统计学意义(P<0.01);治疗组各积分下降值均高于对照组(P<0.05或P<0.01)。两组不同年龄段患者治疗后各积分分值均低于治疗前(P<0.01)。治疗后老年各积分分值治疗组均低于对照组(P<0.01),治疗组各积分下降值均高于对照组(P<0.05或P<0.01);各积分下降值治疗组均高于对照组(P<0.01)。轻、中、重度患者治疗后,两组各分值均低于治疗前(P<0.01)。治疗后,轻、中度患者治疗组的各积分分值均低于对照组,组间比较差异均有统计学意义(P<0.01)。结论和血通脉颗粒联合西药治疗心脑合病痰瘀互结证有效,这种疗效无性别和年龄差异,但可能对病情轻、中度患者的疗效优于重度患者。Objective To evaluate the therapeutic effect of Hexue Tongmai Granules （ granules to harmonize the blood and free the vessels） combined with western medicine for cardio-cerebral-vascular diseases with phlegm-stasis intermingling pattern and its relation with the age, gender and disease severity of patients. Methods Totally 383 cases of cardio-cerebral-vascular diseases with phlegm-stasis intermingling pattern were randomized into the treatment group and control group, with 191 and 192 in each. The treatment group was given Hexue Tongmai Granules and western medicine. The control group was given placebo and western medicine. The therapeutic effect was observed af- ter 8-week treatment. The total score of TCM pattern, angina score and National Institutes of Health Stroke Scale （NIHSS） score were observed and compared. Results The total effective rate of the treatment group and control group was 78.01% and 55.73% respectively, with a significant difference between groups （P 〈 0.05 ）. The scores of＂ patients with different gender were significantly decreased in both groups （P 〈0.01 ）. The scores of patients with dif- ferent gender in the treatment group were lower than those in the control group, especially NIHSS score of male pa- tients （P 〈 0. 05） and all scores of female patients （P 〈 0. 01 ）. The decrement of all scores in the treatment group was significantly higher than that in the control group （P 〈0. 05 or P 〈0.01 ）. The scores of patients of different ages were significantly decreased in both groups （P 〈 0.01 ）. The scores of elderly patients in the treatment group were significantly lower than those in the control group （P 〈 0. 01 ）. The decrement of all scores in the treatment group was significantly higher than that in the control group （P 〈 0.05 or P 〈 0. 01 ）. The scores of patients with mild, moderate or severe disease were significantly decreased in both groups （P 〈 0.01 ）. The scores of patients with mild or moder- ate disease in the

关 键 词：和血通脉颗粒 心脑合病 痰瘀互结 心绞痛 脑梗死 

分 类 号：R541.4[医药卫生—心血管疾病]